ArticleBiophysical journal2005
Cell-transistor coupling: investigation of potassium currents recorded with p- and n-channel FETs.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 66 citations in OpenAlex.
- A portable and cost-effective system for electronic nucleic acid mass measurement.Scientific reports · 2025Article
- Current-Induced Transistor Sensorics with Electrogenic Cells.Biosensors · 2016Review
- ZnO Nanostructure Templates as a Cost-Efficient Mass-Producible Route for the Development of Cellular Networks.Materials (Basel, Switzerland) · 2016Article
- Molecular charge contact biosensing based on the interaction of biologically modified magnetic beads with an ion-sensitive field effect transistor.European biophysics journal : EBJ · 2014Article
- Application of ion-sensitive field effect transistors for ion channel screening.Biosensors & bioelectronics · 2014Article
- Comparative analysis of system identification techniques for nonlinear modeling of the neuron-microelectrode junction.Journal of computational and theoretical nanoscience · 2013Article
- An optimization-based study of equivalent circuit models for representing recordings at the neuron-electrode interface.IEEE transactions on bio-medical engineering · 2012Article
- Transmission electron microscopy study of the cell-sensor interface.Journal of the Royal Society, Interface · 2008Article
- Solution of the Poisson-Nernst-Planck equations in the cell-substrate interface.The European physical journal. E, Soft matter · 2007Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microelectronic-based biosensors that allow noninvasive measurement of cell activity are in the focus of current developments, however, the mechanisms underlying the cell-transistor coupling are not completely understood. In particular, characteristic properties of the extracellular voltage response such as the waveform and amplitude are not satisfactorily described by electrical circuit models. Here we examine the electrical coupling between a nonmetallized field-effect transistor (FET) and a cell line expressing a voltage-gated EAG K+ channel. The activation kinetics of this channel depends on the voltage pulse protocol and extracellular divalent cations. This feature allows testing, whether the extracellular voltage signal recorded with the FET faithfully tracks the current simultaneously recorded with the patch-clamp technique. We find that the FET signals contain different kinetic components that cannot be entirely explained by equivalent electrical-circuit models. Rather, we suggest that changes in ion concentration in the small cleft between cell and FET may change the surface potential of the FET. This study provides evidence that the electrochemical processes at the cell-transistor interface are complex and that at least two different mechanisms contribute to the shape and amplitude of transistor signals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.