ArticleBiophysical journal2005
Time- and voltage-dependent components of Kv4.3 inactivation.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary.Circulation · 2008Guideline
- Differential Effects of the Betablockers Carvedilol, Metoprolol and Bisoprolol on Cardiac KInternational journal of molecular sciences · 2023Article
- A Mathematical Model of the Human Cardiac NaThe Journal of membrane biology · 2019Article
- Reconstruction of Cell Surface Densities of Ion Pumps, Exchangers, and Channels from mRNA Expression, Conductance Kinetics, Whole-Cell Calcium, and Current-Clamp Voltage Recordings, with an Application to Human Uterine Smooth Muscle Cells.PLoS computational biology · 2016Article
- Voltage gating by molecular subunits of Na+ and K+ ion channels: higher-dimensional cubic kinetics, rate constants, and temperature.Journal of neurophysiology · 2015Article
- Electronic "expression" of the inward rectifier in cardiocytes derived from human-induced pluripotent stem cells.Heart rhythm · 2013Article
- Effect of mosapride on Kv4.3 potassium channels expressed in CHO cells.Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
- Inhibition of Kv4.3 potassium channels by trazodone.Naunyn-Schmiedeberg's archives of pharmacology · 2013Article
- Markov models of use-dependence and reverse use-dependence during the mouse cardiac action potential.PloS one · 2012Article
- Inhibition of Kv4.3 by genistein via a tyrosine phosphorylation-independent mechanism.American journal of physiology. Cell physiology · 2011Article
- Mechanisms of closed-state inactivation in voltage-gated ion channels.The Journal of physiology · 2011Review
- A model of the interaction between N-type and C-type inactivation in Kv1.4 channels.Biophysical journal · 2011Article
- Closed-state inactivation in Kv4.3 isoforms is differentially modulated by protein kinase C.American journal of physiology. Cell physiology · 2009Article
- K+ current changes account for the rate dependence of the action potential in the human atrial myocyte.American journal of physiology. Heart and circulatory physiology · 2009Article
- Ca/calmodulin kinase II differentially modulates potassium currents.Circulation. Arrhythmia and electrophysiology · 2009Article
- Dynamic coupling of voltage sensor and gate involved in closed-state inactivation of kv4.2 channels.The Journal of general physiology · 2009Article
- The neuronal Kv4 channel complex.Neurochemical research · 2008Review
- Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons.The Journal of physiology · 2008Article
- Role of N-terminal domain and accessory subunits in controlling deactivation-inactivation coupling of Kv4.2 channels.Biophysical journal · 2008Article
- Mechanism of the modulation of Kv4:KChIP-1 channels by external K+.Biophysical journal · 2008Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Kv4.3 inactivation is a complex multiexponential process, which can occur from both closed and open states. The fast component of inactivation is modulated by the N-terminus, but the mechanisms mediating the other components of inactivation are controversial. We studied inactivation of Kv4.3 expressed in Xenopus laevis oocytes, using the two-electrode voltage-clamp technique. Inactivation during 2000 ms pulses at potentials positive to the activation threshold was described by three exponents (46 +/- 3, 152 +/- 13, and 930 +/- 50 ms at +50 mV, n = 7) whereas closed-state inactivation (at potentials below threshold) was described by two exponents (1079 +/- 119 and 3719 +/- 307 ms at -40 mV, n = 9). The fast component of open-state inactivation was dominant at potentials positive to -20 mV. Negative to -30 mV, the intermediate and slow components dominated inactivation. Inactivation properties were dependent on pulse duration. Recovery from inactivation was strongly dependent on voltage and pulse duration. We developed an 11-state Markov model of Kv4.3 gating that incorporated a direct transition from the open-inactivated state to the closed-inactivated state. Simulations with this model reproduced open- and closed-state inactivation, isochronal inactivation relationships, and reopening currents. Our data suggest that inactivation can proceed primarily from the open state and that multiple inactivation components can be identified.
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