ArticleBiophysical journal2005
Radial compression of microtubules and the mechanism of action of taxol and associated proteins.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 78 citations in OpenAlex.
- Eg5 activity and density-driven bundling organize the human metaphase mitotic spindle independently of spindle bipolarity.bioRxiv : the preprint server for biology · 2026Article
- Structure and dynamics of motor-driven microtubule bundles.Soft matter · 2024Article
- Article
- Tuning the Properties of Active Microtubule Networks by Depletion Forces.Langmuir : the ACS journal of surfaces and colloids · 2021Article
- Downregulation of GPSM2 is associated with primary resistance to paclitaxel in breast cancer.Oncology reports · 2020Article
- Structural analysis of healthy and cancerous epithelial-type breast cells by nanomechanical spectroscopy allows us to obtain peculiarities of the skeleton and junctions.Nanoscale advances · 2019Article
- Altered skeletal muscle microtubule-mitochondrial VDAC2 binding is related to bioenergetic impairments after paclitaxel but not vinblastine chemotherapies.American journal of physiology. Cell physiology · 2019Article
- Article
- Structure and Intermolecular Interactions between L-Type Straight Flagellar Filaments.Biophysical journal · 2017Article
- Tubulin acetylation protects long-lived microtubules against mechanical ageing.Nature cell biology · 2017Article
- Role of tau in the spatial organization of axonal microtubules: keeping parallel microtubules evenly distributed despite macromolecular crowding.Cellular and molecular life sciences : CMLS · 2016Article
- The Dark Matter of Biology.Biophysical journal · 2016Review
- The effect of multivalent cations and Tau on paclitaxel-stabilized microtubule assembly, disassembly, and structure.Advances in colloid and interface science · 2016Review
- Cardioprotective effect of royal jelly on paclitaxel-induced cardio-toxicity in rats.Iranian journal of basic medical sciences · 2016Article
- Direct force measurements reveal that protein Tau confers short-range attractions and isoform-dependent steric stabilization to microtubules.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Simulated cytoskeletal collapse via tau degradation.PloS one · 2014Article
- Brownian dynamics of subunit addition-loss kinetics and thermodynamics in linear polymer self-assembly.Biophysical journal · 2013Article
- Mechanical properties of doubly stabilized microtubule filaments.Biophysical journal · 2013Article
- Nanoscale assembly in biological systems: from neuronal cytoskeletal proteins to curvature stabilizing lipids.Advanced materials (Deerfield Beach, Fla.) · 2011Review
- Acute Taxol nephrotoxicity: Histological and ultrastructural studies of mice kidney parenchyma.Saudi journal of biological sciences · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Microtubules (MTs) are hollow cylindrical polymers composed of alphabeta-tubulin heterodimers that align head-to-tail in the MT wall, forming linear protofilaments that interact laterally. We introduce a probe of the interprotofilament interactions within MTs and show that this technique gives insight into the mechanisms by which MT-associated proteins (MAPs) and taxol stabilize MTs. In addition, we present further measurements of the mechanical properties of MT walls, MT-MT interactions, and the entry of polymers into the MT lumen. These results are obtained from a synchrotron small angle x-ray diffraction (SAXRD) study of MTs under osmotic stress. Above a critical osmotic pressure, P(cr), we observe rectangular bundles of MTs whose cross sections have buckled to a noncircular shape; further increases in pressure continue to distort MTs elastically. The P(cr) of approximately 600 Pa provides, for the first time, a measure of the bending modulus of the interprotofilament bond within an MT. The presence of neuronal MAPs greatly increases P(cr), whereas surprisingly, the cancer chemotherapeutic drug taxol, which suppresses MT dynamics and inhibits MT depolymerization, does not affect the interprotofilament interactions. This SAXRD-osmotic stress technique, which has enabled measurements of the mechanical properties of MTs, should find broad application for studying interactions between MTs and of MTs with MAPs and MT-associated drugs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.