ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2005
The C. elegans ortholog of mammalian Ku70, interacts with insulin-like signaling to modulate stress resistance and life span.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 21 citations in OpenAlex.
- University of Southern California and buck institute nathan shock center: multidimensional models of aging.GeroScience · 2021Article
- Knock-down ofAging · 2021Article
- Caenorhabditis elegans RMI2 functional homolog-2 (RMIF-2) and RMI1 (RMH-1) have both overlapping and distinct meiotic functions within the BTR complex.PLoS genetics · 2021Article
- Loss of Function of Scavenger Receptor SCAV-5 ProtectsFrontiers in cellular and infection microbiology · 2021Article
- FOXO/DAF-16 Activation Slows Down Turnover of the Majority of Proteins in C. elegans.Cell reports · 2016Article
- Rapid and precise engineering of the Caenorhabditis elegans genome with lethal mutation co-conversion and inactivation of NHEJ repair.Genetics · 2015Article
- Extreme-longevity mutations orchestrate silencing of multiple signaling pathways.Biochimica et biophysica acta · 2009Review
- Pharmacogenetic analysis of lithium-induced delayed aging in Caenorhabditis elegans.The Journal of biological chemistry · 2008Article
- Relationship between mitochondrial electron transport chain dysfunction, development, and life extension in Caenorhabditis elegans.PLoS biology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The mammalian Ku heterodimer has important roles in DNA double strand break repair, telomere maintenance, cell cycle checkpoint-arrest, tumor suppression, and cellular stress resistance. To investigate the evolutionarily conserved functions of Ku, we knocked down expression by RNA interference (RNAi) of Ku genes in C. elegans. We found that C. elegans Ku70 (CKU-70) is required for resistance to genotoxic stress, regulates cytotoxic stress responses, and influences aging. The latter effects are dependent on an IGF-1/insulin-like signaling pathway previously shown to affect life span. Reduction of CKU-70 activity amplifies the aging phenotype of long-lived insulin receptor daf-2 mutations in a daf-16-dependent manner. These observations support the view that organismal stress resistance determines life span and Ku70 modulates these effects.
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Registered trials
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