ArticleAmerican journal of human genetics1992
A 1.6-Mb contig of yeast artificial chromosomes around the human factor VIII gene reveals three regions homologous to probes for the DXS115 locus and two for the DXYS64 locus.
Article in American journal of human genetics, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- Article
- Mutation detection and inhibitor risk in Iranian patients with Hemophilia A: Six novel mutations.Clinical case reports · 2020Article
- Factor VIII inhibitor development in Egyptian hemophilia patients: does intron 22 inversion mutation play a role?Italian journal of pediatrics · 2020Article
- Accurate, simple, and inexpensive assays to diagnoseBlood advances · 2016Article
- Eighteen years of molecular genotyping the hemophilia inversion hotspot: from southern blot to inverse shifting-PCR.International journal of molecular sciences · 2011Review
- HindIII-based restriction fragment length polymorphism in hemophilic and nonhemophilic patients.Journal of natural science, biology, and medicine · 2010Article
- Familial skewed X inactivation: a molecular trait associated with high spontaneous-abortion rate maps to Xq28.American journal of human genetics · 1997Article
- Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Flipping the tip of the X.Nature genetics · 1993Article
- Genetic mapping of the X-linked dominant mutations striated (Str) and bare patches (Bpa) to a 600-kb region of the mouse X chromosome: implications for mapping human disorders in Xq28.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
- Genome mapping by arbitrary amplification of yeast artificial chromosomes.Mammalian genome : official journal of the International Mammalian Genome Society · 1993Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Two yeast artificial chromosome (YAC) libraries were screened for probes in Xq28, around the gene for coagulation factor VIII (F8). A set of 30 YACs were recovered and assembled into a contig spanning at least 1.6 Mb from the DXYS64 locus to the glucose 6-phosphate dehydrogenase gene (G6PD). Overlaps among the YACs were determined by several fingerprinting techniques and by additional probes generated from YAC inserts by using Alu-vector or ligation-mediated PCR. Analysis of more than 30 probes and sequence-tagged sites (STSs) made from the region revealed the presence of several homologous genomic segments. For example, a probe for the DXYS64 locus, which maps less than 500 kb 5' of F8, detects a similar but not identical locus between F8 and G6PD. Also, a probe for the DXS115 locus detects at least three identical copies in this region, one in intron 22 of F8 and at least two more, which are upstream of the 5' end of the gene. Comparisons of genomic and YAC DNA suggest that the multiple loci are not created artifactually during cloning but reflect the structure of uncloned human DNA. On the basis of these data, the most likely order for the loci analyzed is tel-DXYS61-DXYS64-(DXS115-3-DXS115-2)-5'F8-(D XS115-1)-3'F8-G6PD.
Indexed as
Identifiers
1609806PMC1682886What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.