ArticleWorld journal of gastroenterology2005
Anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium-induced colitis of rats.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Oxymatrine for inflammatory bowel disease in preclinical studies: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
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- Natural and herbal compounds targeting breast cancer, a review based on cancer stem cells.Iranian journal of basic medical sciences · 2020Review
- Combination of oxymatrine and diammonium glycyrrhizinate significantly mitigates mice allergic contact dermatitis induced by dinitrofluorobenzene.Experimental biology and medicine (Maywood, N.J.) · 2019Article
- Supercritical Fluid Extract ofInternational journal of molecular sciences · 2019Article
- T cell--associated immunoregulation and antiviral effect of oxymatrine in hydrodynamic injection HBV mouse model.Acta pharmaceutica Sinica. B · 2017Article
- Oxymatrine on Hsp90a expression and apoptosis in a model of lung ischemia-reperfusion injury.Experimental and therapeutic medicine · 2017Article
- Recent Trends in Pharmacological Activity of Alkaloids in Animal Colitis: Potential Use for Inflammatory Bowel Disease.Evidence-based complementary and alternative medicine : eCAM · 2017Review
- Oxymatrine lightened the inflammatory response of LPS-induced mastitis in mice through affecting NF-κB and MAPKs signaling pathways.Inflammation · 2014Article
- Role of DOR-β-arrestin1-Bcl2 signal transduction pathway and intervention effects of oxymatrine in ulcerative colitis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2014Article
- Oxymatrine attenuates diabetes-associated cognitive deficits in rats.Acta pharmacologica Sinica · 2014Article
- Oxymatrine improves intestinal epithelial barrier function involving NF-κB-mediated signaling pathway in CCl4-induced cirrhotic rats.PloS one · 2014Article
- Anti-inflammatory Effects of Oxymatrine Through Inhibition of Nuclear Factor-kappa B and Mitogen-activated Protein Kinase Activation in Lipopolysaccharide-induced BV2 Microglia Cells.Iranian journal of pharmaceutical research : IJPR · 2013Article
- Add-on effect of chinese herbal medicine bath to phototherapy for psoriasis vulgaris: a systematic review.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Oxymatrine prevents NF-κB nuclear translocation and ameliorates acute intestinal inflammation.Scientific reports · 2013Article
- Role of β2-adrenoceptor-β-arrestin2-nuclear factor-κB signal transduction pathway and intervention effects of oxymatrine in ulcerative colitis.Chinese journal of integrative medicine · 2012Article
- Oxymatrine ameliorates L-arginine-induced acute pancreatitis in rats.Inflammation · 2012Article
- Immunoprotective Effect of Probiotic Dahi Containing Lactobacillus acidophilus and Bifidobacterium bifidum on Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice.Probiotics and antimicrobial proteins · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the anti-inflammatory mechanism of oxymatrine in dextran sulfate sodium (DSS)-induced colitis of rats.
methodsAcute colitis was induced by giving 2% DSS orally in drinking water for 8 d. Twenty-six male rats were randomized into oxymatrine-treated group (group A, 10 rats), DSS control (group B, 10 rats) and normal control (group C, 6 rats). The rats in group A were injected muscularly with oxymatrine at the dosage of 63 mg/(kg.d) from d 1 to 11 and drank 2% DSS solution from d 4 to 11. The rats in group B were treated with 0.9% saline in an equal volume as group A and drank 2% DSS solution from d 4 to 11. The rats in group C were treated with 0.9% saline as group B from d 1 to 11 and drank water normally. Diarrhea and bloody stool as well as colonic histology were observed. The levels of serum tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) were determined by ELISA, and nuclear factor-kappaB (NF-kappaB) activity and the expression of inter-cellular adhesion molecule-1 (ICAM-1) in colonic mucosa were detected by immunohistochemistry method.
resultsCompared with DSS control group, the inflammatory symptoms and histological damages of colonic mucosa in oxymatrine-treated group were significantly improved, the serum levels of TNF-alpha, IL-6, and the expression of NF-kappaB, ICAM-1 in colonic mucosa were significantly reduced.
conclusionThe fact that oxymatrine can reduce the serum levels of TNF-alpha, IL-6, and the expression of NF-kappaB and ICAM-1 in colonic mucosa in DSS-induced colitis of rats indicates that oxymatrine may ameliorate the colonic inflammation and thus alleviate diarrhea and bloody stool.
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