ArticleWorld journal of gastroenterology2005
Appendix is a priming site in the development of ulcerative colitis.
Article in World journal of gastroenterology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Pooled it
- Surgery and risk for multiple sclerosis: a systematic review and meta-analysis of case-control studies.BMC neurology · 2013Pooled it
- Histopathological Findings of Appendix Specimens in Quiescent Ulcerative Colitis: Correlations With Clinical Outcomes in the ACCURE Trial.United European gastroenterology journal · 2026Trial
- Appendectomy as a Risk Factor for Bacteremic Biliary Tract Infection Caused by Antibiotic-Resistant Pathogens.BioMed research international · 2017Trial
- Trial
- The appendix and ulcerative colitis: from an unsolved connection to a therapeutic strategy.Translational gastroenterology and hepatology · 2026Article
- Distinct microbiota composition and dendritic cell activation in the appendix microenvironment of ulcerative colitis patients.Gut microbes · 2025Article
- Article
- Cholangioscope-assisted ERAT for the diagnoses and treatment of ulcerative colitis with appendiceal orifice inflammation: a case report and a literature review.International journal of colorectal disease · 2025Review
- The appendix and ulcerative colitis - an unsolved connection.Nature reviews. Gastroenterology & hepatology · 2023Review
- Appendix and Ulcerative Colitis: a Key to Explaining the Pathogenesis and Directing Novel Therapies?Inflammatory bowel diseases · 2023Review
- Significance of diagnosis and prognosis for appendiceal orifice inflammation in ulcerative colitis: a real-world study.BMJ open · 2022Observational
- Article
- Influence of Environmental Factors in the Development and Outcomes of Inflammatory Bowel Disease.Gastroenterology & hepatology · 2019Article
- Prior Appendectomy and the Onset and Course of Crohn's Disease in Chinese Patients.Gastroenterology research and practice · 2019Article
- Pathophysiology of the Appendix in Ulcerative Colitis.The American journal of gastroenterology · 2018Article
- Effects of Appendectomy on the Onset and Course of Ulcerative Colitis in Chinese Patients.Gastroenterology research and practice · 2018Article
- Clinical Predictors and Natural History of Disease Extension in Patients with Ulcerative Proctitis.Inflammatory bowel diseases · 2017Article
- Modifiable Environmental Factors in Inflammatory Bowel Disease.Current gastroenterology reports · 2017Review
- Pathogenesis and Carcinogenesis of the Appendix in Ulcerative Colitis.The American journal of gastroenterology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe role of the appendix has been highlighted in the pathogenesis of ulcerative colitis (UC). The aims of this study were to elucidate the immuno-imbalances in the appendix of UC patients, and to clarify the role of the appendix in the development of UC.
methodsColonoscopic biopsy specimens of the appendix, transverse colon, and rectum were obtained from 86 patients with UC: active pancolitis (A-Pan; n = 15), active left-sided colitis (A-Lt; n = 25), A-Lt with appendiceal involvement (A-Lt/Ap; n = 10), inactive pancolitis (I-Pan; n = 14), and inactive left-sided colitis (I-Lt; n = 22), and from controls. In the isolated mucosal T cells, the CD4/CD8 ratio and proportion of activated CD4+ T cells were investigated, and compared with controls.
resultsIn the appendix, the CD4/CD8 ratio significantly increased in A-Lt and A-Lt/Ap. The ratio in the appendix also tended to increase in A-Pan. In the rectum, the ratio significantly increased in all UC groups. In the appendix, the proportion of CD4+CD69+ (early activation antigen) T cells significantly increased in all UC groups. In the rectum, the proportion of CD4+CD69+ T cells significantly increased only in A-Pan. The proportion of CD4+HLA-DR+ (mature activation antigen) T cells significantly increased only in the rectum of A-Pan, but not in the other areas of any groups.
conclusionThe increased CD4/CD8 ratio and predominant infiltration of CD4+CD69+ T cells in the appendix suggest that the appendix is a priming site in the development of UC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.