ArticleThe EMBO journal2005
AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism.
Article in The EMBO journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 60 citations in OpenAlex.
- Extracellular vesicles in β cell biology: Role of lipids in vesicle biogenesis, cargo, and intercellular signaling.Molecular metabolism · 2022Review
- ORP5 and ORP8: Sterol Sensors and Phospholipid Transfer Proteins at Membrane Contact Sites?Biomolecules · 2020Review
- ESCRT-dependent protein sorting is required for the viability of yeast clathrin-mediated endocytosis mutants.Traffic (Copenhagen, Denmark) · 2020Article
- Mesenchymal Stem Cell (MSC)-Derived Extracellular Vesicles: Potential Therapeutics as MSC Trophic Mediators in Regenerative Medicine.Anatomical record (Hoboken, N.J. : 2007) · 2020Review
- Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes.Nature reviews. Molecular cell biology · 2019Review
- Cholesterol and the journey of extracellular vesicles.Journal of lipid research · 2018Review
- Extracellular vesicles: lipids as key components of their biogenesis and functions.Journal of lipid research · 2018Review
- Advances on the Transfer of Lipids by Lipid Transfer Proteins.Trends in biochemical sciences · 2017Review
- Functional Analysis of Sterol Transporter Orthologues in the Filamentous Fungus Aspergillus nidulans.Eukaryotic cell · 2015Article
- A detour for yeast oxysterol binding proteins.The Journal of biological chemistry · 2012Review
- A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking.The Journal of cell biology · 2011Article
- High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila.Cell metabolism · 2010Article
- Multivesicular body formation requires OSBP-related proteins and cholesterol.PLoS genetics · 2010Article
- The diverse functions of oxysterol-binding proteins.Annual review of cell and developmental biology · 2010Review
- Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues.The Journal of cell biology · 2009Article
- The oxysterol binding protein Kes1p regulates Golgi apparatus phosphatidylinositol-4-phosphate function.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Sterol transport in yeast and the oxysterol binding protein homologue (OSH) family.Biochimica et biophysica acta · 2007Review
- Biogenesis and function of multivesicular bodies.Annual review of cell and developmental biology · 2007Review
- Nonvesicular sterol movement from plasma membrane to ER requires oxysterol-binding protein-related proteins and phosphoinositides.The Journal of cell biology · 2006Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The yeast genome encodes seven oxysterol binding protein homologs, Osh1p-Osh7p, which have been implicated in regulating intracellular lipid and vesicular transport. Here, we show that both Osh6p and Osh7p interact with Vps4p, a member of the AAA (ATPases associated with a variety of cellular activities) family. The coiled-coil domain of Osh7p was found to interact with Vps4p in a yeast two-hybrid screen and the interaction between Osh7p and Vps4p appears to be regulated by ergosterol. Deletion of VPS4 induced a dramatic increase in the membrane-associated pools of Osh6p and Osh7p and also caused a decrease in sterol esterification, which was suppressed by overexpression of OSH7. Lastly, overexpression of the coiled-coil domain of Osh7p (Osh7pCC) resulted in a multivesicular body sorting defect, suggesting a dominant negative role of Osh7pCC possibly through inhibiting Vps4p function. Our data suggest that a common mechanism may exist for AAA proteins to regulate the membrane association of yeast OSBP proteins and that these two protein families may function together to control subcellular lipid transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.