ArticleThe Journal of physiology2005
Maturation of glycinergic inhibition in the gerbil medial superior olive after hearing onset.
Article in The Journal of physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 138 citations in OpenAlex.
- Oligodendrocyte arrangement, identification and morphology in the developing superior olivary complex.Frontiers in cellular neuroscience · 2025Article
- Cellular and synaptic specializations for sub-millisecond precision in the mammalian auditory brainstem.Frontiers in cellular neuroscience · 2025Review
- Developmental fine-tuning of medial superior olive neurons mitigates their predisposition to contralateral sound sources.PLoS biology · 2024Article
- Experience-Dependent Plasticity in Nucleus Laminaris of the Barn Owl.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Structural and Functional Development of Inhibitory Connections from the Medial Nucleus of the Trapezoid Body to the Superior Paraolivary Nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Peripheral Fragile X messenger ribonucleoprotein is required for the timely closure of a critical period for neuronal susceptibility in the ventral cochlear nucleus.Frontiers in cellular neuroscience · 2023Article
- Synapse Maturation and Developmental Impairment in the Medial Nucleus of the Trapezoid Body.Frontiers in integrative neuroscience · 2022Review
- Auditory Brainstem Models: Adapting Cochlear Nuclei Improve Spatial Encoding by the Medial Superior Olive in Reverberation.Journal of the Association for Research in Otolaryngology : JARO · 2021Article
- Ambient noise exposure induces long-term adaptations in adult brainstem neurons.Scientific reports · 2021Article
- Activity-Dependent Calcium Signaling in Neurons of the Medial Superior Olive during Late Postnatal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Minimal Number of Required Inputs for Temporally Precise Action Potential Generation in Auditory Brainstem Nuclei.Frontiers in cellular neuroscience · 2020Article
- Principal Neurons in the Anteroventral Cochlear Nucleus Express Cell-Type Specific Glycine Receptor α Subunits.Neuroscience · 2019Article
- Article
- Enhancement of phase-locking in rodents. I. An axonal recording study in gerbil.Journal of neurophysiology · 2017Article
- Theory of optimal balance predicts and explains the amplitude and decay time of synaptic inhibition.Nature communications · 2017Article
- Developmental Shift of Inhibitory Transmitter Content at a Central Auditory Synapse.Frontiers in cellular neuroscience · 2017Article
- Octopus Cells in the Posteroventral Cochlear Nucleus Provide the Main Excitatory Input to the Superior Paraolivary Nucleus.Frontiers in neural circuits · 2017Article
- Physiology and anatomy of neurons in the medial superior olive of the mouse.Journal of neurophysiology · 2016Article
- High-Frequency Resonance in the Gerbil Medial Superior Olive.PLoS computational biology · 2016Article
- Acoustic trauma slows AMPA receptor-mediated EPSCs in the auditory brainstem, reducing GluA4 subunit expression as a mechanism to rescue binaural function.The Journal of physiology · 2016Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurones of the medial superior olive (MSO) are the most temporally sensitive neurones in the brain. They respond to the arrival time difference of sound at the two ears with a microsecond resolution; these interaural time differences are used to localize low-frequency sounds. In addition to the excitatory inputs from each ear, the MSO neurones also receive binaural glycinergic projections, which have a critical role in sound localization processing. Recently, it was shown that the glycinergic input to the MSO undergoes an experience-dependent structural reorganization after hearing onset. To explore the maturation of inhibition during the development of sound localization on a cellular level, glycinergic currents and potentials were measured in gerbil MSO principal cells from postnatal (P) day P12-P25 by whole-cell patch-clamp recordings. The synaptic glycinergic currents accelerated to rapid decay kinetics (approximately 2 ms) and rise times (approximately 0.4 ms) after hearing onset, reaching maturity around P17. Since the kinetics of miniature glycinergic currents did not change with age, it is likely that a higher degree of transmitter release synchrony is the underlying mechanism influencing the acceleration of the kinetics. During the same period, the synaptic glycinergic potentials accelerated four-fold, largely as a result of a prominent decrease in input resistance. In accordance with a reorganization of the glycinergic inputs, the evoked peak conductances decreased more than two-fold, together with a three-fold reduction in the frequency of miniature events after hearing onset. These age-dependent changes were absent in animals that had been reared in omni-directional noise, indicating that an experience-dependent pruning of synaptic inputs is important for the maturation of functional inhibition in the MSO. Taken together, these striking developmental adjustments of the glycinergic inhibition in the MSO most probably reflect an adaptation to improve the encoding of auditory cues with great temporal precision and fidelity during the maturation of sound localization behaviour.
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