ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2005
Prospects and pitfalls in whole genome association studies.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessment of systematic effects of methodological characteristics on candidate genetic associations.Human genetics · 2013Pooled it
- Article
- Dissecting the Mechanisms Underlying Unusually Successful Human Health Span and Life Span.Cold Spring Harbor perspectives in medicine · 2015Review
- STrengthening the REporting of Genetic Association studies (STREGA)--an extension of the STROBE statement.European journal of clinical investigation · 2009Article
- Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE Statement.Human genetics · 2009Article
- STrengthening the REporting of Genetic Association Studies (STREGA): an extension of the STROBE statement.PLoS medicine · 2009Article
- Strengthening the reporting of genetic association studies (STREGA): an extension of the STROBE statement.European journal of epidemiology · 2009Review
- Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics approach.BioData mining · 2008Article
- Article
- Use of stochastic simulations to investigate the power and design of a whole genome association study using single nucleotide polymorphism arrays in farm animals.Journal of Zhejiang University. Science. B · 2007Article
- Genetic determinants of human health span and life span: progress and new opportunities.PLoS genetics · 2007Review
- Neuroimaging endophenotypes: strategies for finding genes influencing brain structure and function.Human brain mapping · 2007Review
- Bayesian graphical models for genomewide association studies.American journal of human genetics · 2006Article
- Introduction: genetic variation and human health.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Recent large-scale studies of common genetic variation throughout the human genome are making it feasible to conduct whole genome studies of genotype-phenotype associations. Such studies have the potential to uncover novel contributors to common complex traits and thus lead to insights into the aetiology of multifactorial phenotypes. Despite this promise, it is important to recognize that the availability of genetic markers and the ability to assay them at realistic cost does not guarantee success of this approach. There are a number of practical issues that require close attention, some forms of allelic architecture are not readily amenable to the association approach with even the most rigorous design, and doubtless new hurdles will emerge as the studies begin. Here we discuss the promise and current challenges of the whole genome approach, and raise some issues to consider in interpreting the results of the first whole genome studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.