ReviewCell2005
Splicing misplaced.
Review in Cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- The Novel Role of Noncoding RNAs in Modulating Platelet Function: Implications in Activation and Aggregation.International journal of molecular sciences · 2023Review
- Splicing of platelet resident pre-mRNAs upon activation by physiological stimuli results in functionally relevant proteome modifications.Scientific reports · 2018Article
- Platelets in Pulmonary Immune Responses and Inflammatory Lung Diseases.Physiological reviews · 2016Review
- Platelets as cellular effectors of inflammation in vascular diseases.Circulation research · 2013Review
- Platelet mRNA: the meaning behind the message.Current opinion in hematology · 2012Review
- Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum.Seminars in immunopathology · 2012Review
- The septic milieu triggers expression of spliced tissue factor mRNA in human platelets.Journal of thrombosis and haemostasis : JTH · 2011Article
- Signal-dependent protein synthesis by activated platelets: new pathways to altered phenotype and function.Arteriosclerosis, thrombosis, and vascular biology · 2008Review
- Signal-dependent splicing of tissue factor pre-mRNA modulates the thrombogenicity of human platelets.The Journal of experimental medicine · 2006Article
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Newly synthesized transcripts are usually spliced during transcription or immediately thereafter. So pre-mRNA splicing has been presumed to occur exclusively in the cell nucleus. In this issue of Cell, Denis et al. (2005) now report the presence of functional spliceosomes and signal-dependent pre-mRNA splicing in the cytoplasm of platelets.
Indexed as
Identifiers
16096050What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.