ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Cholecystokinin activates orexin/hypocretin neurons through the cholecystokinin A receptor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed, 142 citations in OpenAlex.
- Functional Plasticity of Orexin/Hypocretin Neurons Balances Stress States.Biological psychiatry · 2026Review
- Social defeat stress responses in the stress alternative model are dependent on sex and anterior basolateral amygdala orexin 2 receptors.Biology of sex differences · 2026Article
- What do the mushroom bodies do for the insect brain? Twenty-five years of progress.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Neurolysin Knockout Mice in a Diet-Induced Obesity Model.International journal of molecular sciences · 2023Article
- Repeated exposure to kairomone-containing coffee odor improves abnormal olfactory behaviors in heterozygous oxytocin receptor knock-in mice.Frontiers in behavioral neuroscience · 2022Article
- Sleep complaints are associated with increased suicide risk independently of psychiatric disorders: results from a national 3-year prospective study.Molecular psychiatry · 2021Article
- The dynamic regulation of appetitive behavior through lateral hypothalamic orexin and melanin concentrating hormone expressing cells.Physiology & behavior · 2021Review
- A Perspective of Epigenetic Regulation in Radiotherapy.Frontiers in cell and developmental biology · 2021Review
- Heterogeneity of Hypocretin/Orexin Neurons.Frontiers of neurology and neuroscience · 2021Review
- NanoLuc Bioluminescence-Driven Photodynamic Activation of Cholecystokinin 1 Receptor with Genetically-Encoded Protein Photosensitizer MiniSOG.International journal of molecular sciences · 2020Article
- Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- TMEM16B determines cholecystokinin sensitivity of intestinal vagal afferents of nodose neurons.JCI insight · 2019Article
- Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states.Nature neuroscience · 2018Article
- Non-Rapid Eye Movement Sleep Parasomnias and Migraine: A Role of Orexinergic Projections.Frontiers in neurology · 2018Article
- Functional Differentiation of Cholecystokinin-Containing Interneurons Destined for the Cerebral Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Orexin System: The Key for a Healthy Life.Frontiers in physiology · 2017Review
- Orexin/Hypocretin System: Role in Food and Drug Overconsumption.International review of neurobiology · 2017Review
- Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour.The Journal of physiology · 2016Review
- Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders.Current psychiatry reports · 2016Review
- Fluorescence Lifetime Imaging of Apoptosis.Tomography (Ann Arbor, Mich.) · 2015Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Orexin A and B are neuropeptides implicated in the regulation of sleep/wakefulness and energy homeostasis. The regulatory mechanism of the activity of orexin neurons is not precisely understood. Using transgenic mice in which orexin neurons specifically express yellow cameleon 2.1, we screened for factors that affect the activity of orexin neurons (a total of 21 peptides and six other factors were examined) and found that a sulfated octapeptide form of cholecystokinin (CCK-8S), neurotensin, oxytocin, and vasopressin activate orexin neurons. The mechanisms that underlie CCK-8S-induced activation of orexin neurons were studied by both calcium imaging and slice patch-clamp recording. CCK-8S induced inward current in the orexin neurons. The CCKA receptor antagonist lorglumide inhibited CCK-8S-induced activation of orexin neurons, whereas the CCKB receptor agonists CCK-4 (a tetrapeptide form of cholecystokinin) and nonsulfated CCK-8 had little effect. The CCK-8S-induced increase in intracellular calcium concentration was eliminated by removing extracellular calcium but not by an addition of thapsigargin. Nifedipine, omega-conotoxin, omega-agatoxin, 4-ethylphenylamino-1,2-dimethyl-6-methylaminopyrimidinium chloride, and SNX-482 had little effect, but La3+, Gd3+, and 2-aminoethoxydiphenylborate inhibited CCK-8S-induced calcium influx. Additionally, the CCK-8S-induced inward current was dramatically enhanced in the calcium-free solution and was inhibited by the cation channel blocker SKF96365, suggesting an involvement of extracellular calcium-sensitive cation channels. CCK-8S did not induce an increase in intracellular calcium concentration when membrane potential was clamped at -60 mV, suggesting that the calcium increase is induced by depolarization. The evidence presented here expands our understanding of the regulation of orexin neurons and the physiological role of CCK in the CNS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.