Evidence map›Paper›PMID 16092524›Full record

ReviewMolecular membrane biology

Structural and dynamic properties of bacterial type IV secretion systems (review).

Peter J Christie, Eric Cascales

Abstract readReview
In one paragraph

Review in Molecular membrane biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. Article
  2. The R plasmid pRAS2 in the fish pathogenFrontiers in microbiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Isolation and Genome Analysis ofFrontiers in plant science · 2022
    Article
  8. Review
  9. Implication of the Type IV Secretion System in the Pathogenicity ofFrontiers in cellular and infection microbiology · 2021
    Article
  10. Article
  11. Review
  12. Article
  13. Inhibitory Effects of Menadione onInternational journal of molecular sciences · 2019
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Peter J ChristieDepartment of Microbiology and Molecular Genetics, UT-Houston Medical School, Houston, Texas 77030, USA. Peter.J.Christie@uth.tmc.edu
Eric Cascales

Funding

TRANSLOCATION OF DNA ACROSS THE AGROBACTERIUM ENVELOPER01GM048746 · NIGMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI CHRISTIE, PETER J. · 1998 to 2018
$6.9M
NIGMS NIH HHS GM47846NIGMS NIH HHS R01 GM048746
6 · The paper itself

Abstract

The type IV secretion systems (T4SS) are widely distributed among the gram-negative and -positive bacteria. These systems mediate the transfer of DNA and protein substrates across the cell envelope to bacterial or eukaryotic cells generally through a process requiring direct cell-to-cell contact. Bacteria have evolved T4SS for survival during establishment of pathogenic or symbiotic relationships with eukaryotic hosts. The Agrobacterium tumefaciens VirB/D4 T4SS and related conjugation machines serve as models for detailed mechanistic studies aimed at elucidating the nature of translocation signals, machine assembly pathways and architectures, and the dynamics of substrate translocation. The A. tumefaciens VirB/D4 T4SS are polar-localized organelles composed of a secretion channel and an extracellular T pilus. These T4SS are assembled from 11 or more subunits. whose membrane topologies, intersubunit contacts and, in some cases, 3-dimensional structures are known. Recently, powerful in vivo assays have identified C-terminal translocation signals, defined for the first time the translocation route for a DNA substrate through a type IV secretion channel, and supplied evidence that ATP energy consumption contributes to a late stage of machine morphogenesis. Together, these recent findings describe the mechanics of type IV secretion in unprecedented detail.

Indexed as

Adenosine TriphosphateAgrobacterium tumefaciensBacterial ProteinsBiological TransportConjugation, GeneticDNA, BacterialGram-Negative BacteriaGram-Positive BacteriaMembrane ProteinsProtein TransportVirulence FactorsAdenosine TriphosphateBacterial ProteinsDNA, BacterialMembrane ProteinstonB protein, BacteriaVirulence Factors

Identifiers

PMID16092524
PMCPMC3921681

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.