ReviewEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2005
Cartilage and bone tissue engineering for reconstructive head and neck surgery.
Review in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 85 citations in OpenAlex.
- Hybrid Reconstruction in Head and Neck Surgery: Integration of Virtual Planning, Navigation, and Robotic Microsurgery.Journal of clinical medicine · 2026Review
- Evaluation of Bioprinted Autologous Cartilage Grafts in an Immunocompetent Rabbit Model.Advanced therapeutics · 2024Article
- In vivo efficacy of 3D-printed elastin-gelatin-hyaluronic acid scaffolds for regeneration of nasal septal cartilage defects.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Development and Characterization of Acellular Caprine Choncal Cartilage Matrix for Tissue Engineering Applications.Cartilage · 2021Article
- The use of a novel deer antler decellularized cartilage-derived matrix scaffold for repair of osteochondral defects.Journal of biological engineering · 2021Article
- Antler stem cells and their potential in wound healing and bone regeneration.World journal of stem cells · 2021Review
- The effect of two phosphodiesterase inhibitors on bone healing in mandibular fractures (animal study in rats).Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2020Article
- The Application of Fibrin/Hyaluronic Acid-Poly(l-Lactic-Tissue engineering and regenerative medicine · 2018Article
- Tissue-Engineered Larynx: Future Applications in Laryngeal Cancer.Current otorhinolaryngology reports · 2017Review
- Marine collagen scaffolds for nasal cartilage repair: prevention of nasal septal perforations in a new orthotopic rat model using tissue engineering techniques.Tissue engineering. Part A · 2013Article
- Development of a biodegradable bone cement for craniofacial applications.Journal of biomedical materials research. Part A · 2012Article
- In vitro study of enhanced osteogenesis induced by HIF-1α-transduced bone marrow stem cells.Cell proliferation · 2011Article
- Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype.Nature protocols · 2010Article
- Cartilage replacement by use of hybrid systems of autologous cells and polyethylene: an experimental study.Journal of materials science. Materials in medicine · 2009Article
- Mold-shaped, nanofiber scaffold-based cartilage engineering using human mesenchymal stem cells and bioreactor.The Journal of surgical research · 2008Article
- Article
- Development of a tissue-engineered vascular graft combining a biodegradable scaffold, muscle-derived stem cells and a rotational vacuum seeding technique.Biomaterials · 2008Article
- Review
- Review
- Classification and diagnosis of ear malformations.GMS current topics in otorhinolaryngology, head and neck surgery · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The loss of cartilage and bone because of congential defects, trauma and after tumor resection is a major clinical problem in head and neck surgery. The most prevalent methods of tissue repair are through autologous grafting or using implants. Tissue engineering applies the principles of engineering and life sciences in order to create bioartificial cartilage and bone. Most strategies for cartilage tissue engineering are based on resorbable biomaterials as temporary scaffolds for chondrocytes or precursor cells. Clinical application of tissue-engineered cartilage for reconstructive head and neck surgery as opposed to orthopedic applications has not been well established. While in orthopedic and trauma surgery engineered constructs or autologous chondrocytes are placed in the immunoprivileged region of joints, the subcutaneous transplant site in the head and neck can lead to strong inflammatory reactions and resorption of the bioartificial cartilage. Encapsulation of the engineered cartilage and modulation of the local immune response are potential strategies to overcome these limitations. In bone tissue engineering the combination of osteoconductive matrices, osteoinductive proteins such as bone morphogenetic proteins and osteogenic progenitor cells from the bone marrow or osteoblasts from bone biopsies offer a variety of tools for bone reconstruction in the craniofacial area. The utility of each technique is site dependent. Osteoconductive approaches are limited in that they merely create a favorable environment for bone formation, but do not play an active role in the recruitment of cells to the defect. Delivery of inductive signals from a scaffold can incite cells to migrate into a defect and control the progression of bone formation. Rapid osteoid matrix production in the defect site is best accomplished by using osteoblasts or progenitor cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.