ArticleBritish journal of cancer2005
Construction of tissue microarrays from prostate needle biopsy specimens.
Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Reinterpretation of prostate cancer pathology by Appl1, Sortilin and Syndecan-1 biomarkers.Scientific data · 2024Article
- Simple method for constructing and repairing tissue microarrays using simple equipment.The Journal of international medical research · 2021Article
- An alternative high output tissue microarray technique.Diagnostic pathology · 2013Article
- Prognostic value of a cell cycle progression signature for prostate cancer death in a conservatively managed needle biopsy cohort.British journal of cancer · 2012Article
- High-density tissue microarrays from prostate needle biopsies.Journal of clinical pathology · 2011Article
- Metabolic, pathologic, and genetic analysis of prostate tissues: quantitative evaluation of histopathologic and mRNA integrity after HR-MAS spectroscopy.NMR in biomedicine · 2010Article
- Overexpression of RAD51 occurs in aggressive prostatic cancer.Histopathology · 2009Article
- An improved method for constructing tissue microarrays from prostate needle biopsy specimens.Journal of clinical pathology · 2009Article
- Biopsy tissue microarray study of Ki-67 expression in untreated, localized prostate cancer managed by active surveillance.Prostate cancer and prostatic diseases · 2009Article
- What is low-risk prostate cancer and what is its natural history?World journal of urology · 2008Review
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Needle biopsies are taken as standard diagnostic specimens for many cancers, but no technique exists for the high-throughput analysis of multiple individual immunohistochemical (IHC) markers using these samples. Here we present a simple and highly reliable technique for constructing tissue microarrays (TMAs) from prostatic needle biopsies. Serial sectioning of the TMAs, called 'Checkerboard TMAs', facilitated expression analysis of multiple proteins using IHC markers. In total, 100% of the analysed biopsies within the TMA both preserved their antigenicity and maintained their morphology. Checkerboard TMAs will allow the use of needle biopsies (i) alongside other tissue specimens (trans-urethral resection of prostates and prostatectomies in the case of prostate cancer) in clinical correlation studies when searching for new prognostic markers, and (ii) in a diagnostic context for assessing expression of multiple proteins in cancers from patients prior to treatment.
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