ArticleOncogene2005
Colon cancer prognosis prediction by gene expression profiling.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Clinical value of prognosis gene expression signatures in colorectal cancer: a systematic review.PloS one · 2012Pooled it
- Prognosis of stage II colon cancer by non-neoplastic mucosa gene expression profiling.Oncogene · 2007Trial
- Prognostic gene expression signature revealed the involvement of mutational pathways in cancer genome.Journal of Cancer · 2020Article
- PDCD10-Deficiency Promotes Malignant Behaviors and Tumor Growth via Triggering EphB4 Kinase Activity in Glioblastoma.Frontiers in oncology · 2020Article
- Prognostic value of chloride channel accessory mRNA expression in colon cancer.Oncology letters · 2019Article
- Loss of programmed cell death 10 activates tumor cells and leads to temozolomide-resistance in glioblastoma.Journal of neuro-oncology · 2019Article
- Extracellular matrix gene expression profiling using microfluidics for colorectal carcinoma stratification.Biomicrofluidics · 2016Article
- Concerted down-regulation of immune-system related genes predicts metastasis in colorectal carcinoma.BMC cancer · 2014Article
- Clinical applications of gene expression in colorectal cancer.Journal of gastrointestinal oncology · 2013Article
- Article
- Right-side and left-side colon cancer follow different pathways to relapse.Molecular carcinogenesis · 2012Article
- Reliability of tumor primary cultures as a model for drug response prediction: expression profiles comparison of tissues versus primary cultures from colorectal cancer patients.Journal of cancer research and clinical oncology · 2012Article
- A systems biology approach identifies SART1 as a novel determinant of both 5-fluorouracil and SN38 drug resistance in colorectal cancer.Molecular cancer therapeutics · 2012Article
- Multiwalled carbon nanotube-induced gene signatures in the mouse lung: potential predictive value for human lung cancer risk and prognosis.Journal of toxicology and environmental health. Part A · 2012Article
- Genome-wide screening of genes regulated by DNA methylation in colon cancer development.PloS one · 2012Article
- Article
- Tumor immunosurveillance in human cancers.Cancer metastasis reviews · 2011Review
- Implementing prognostic and predictive biomarkers in CRC clinical trials.Nature reviews. Clinical oncology · 2011Review
- Genetic prognostic and predictive markers in colorectal cancer.Nature reviews. Cancer · 2009Review
- A factor graph nested effects model to identify networks from genetic perturbations.PLoS computational biology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study assessed the possibility to build a prognosis predictor, based on microarray gene expression measures, in stage II and III colon cancer patients. Tumour (T) and non-neoplastic mucosa (NM) mRNA samples from 18 patients (nine with a recurrence, nine with no recurrence) were profiled using the Affymetrix HGU133A GeneChip. The k-nearest neighbour method was used for prognosis prediction using T and NM gene expression measures. Six-fold cross-validation was applied to select the number of neighbours and the number of informative genes to include in the predictors. Based on this information, one T-based and one NM-based predictor were proposed and their accuracies were estimated by double cross-validation. In six-fold cross-validation, the lowest numbers of informative genes giving the lowest numbers of false predictions (two out of 18) were 30 and 70 with the T and NM gene expression measures, respectively. A 30-gene T-based predictor and a 70-gene NM-based predictor were then built, with estimated accuracies of 78 and 83%, respectively. This study suggests that one can build an accurate prognosis predictor for stage II and III colon cancer patients, based on gene expression measures, and one can use either tumour or non-neoplastic mucosa for this purpose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.