ArticleAJNR. American journal of neuroradiology2005
Abciximab in patients with ruptured intracranial aneurysms.
Article in AJNR. American journal of neuroradiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Glycoprotein IIb/IIIa inhibitors in the treatment of thromboembolic events related to endovascular treatment of cerebral aneurysms-systematic review and meta-analysis.The neuroradiology journal · 2024Pooled it
- Rescue treatment of thromboembolic complications during endovascular treatment of cerebral aneurysms: a meta-analysis.AJNR. American journal of neuroradiology · 2015Pooled it
- Clinical and angiographic follow-up of ruptured intracranial aneurysms treated with endovascular embolization.AJNR. American journal of neuroradiology · 2009Trial
- Abciximab in rescue therapy of thromboembolic events during endovascular treatment of cerebral aneurysms: single center experience of 49 cases.Frontiers in neurology · 2025Article
- Risk Factors for Recanalization after Coil Embolization.Journal of personalized medicine · 2021Article
- Flow diverting devices in acute ruptured blood blister aneurysms: a three centric retrospective study.Acta bio-medica : Atenei Parmensis · 2020Article
- The Utility of Diffusion-Weighted MRI Lesions to Compare the Effects of Different Heparinization Schemes in Intracranial Aneurysms Treated by Endovascular Intervention.Frontiers in neurology · 2020Article
- Safety of Abciximab injection during endovascular treatment of ruptured aneurysms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2015Article
- Review
- Neuroform stent-assisted treatment of intracranial aneurysms: long-term follow-up study of aneurysm recurrence and in-stent stenosis rates.Neuroradiology · 2013Article
- Intraarterial tirofiban thrombolysis for thromboembolisms during coil embolization for ruptured intracranial aneurysms.Journal of cerebrovascular and endovascular neurosurgery · 2012Article
- Stent-assisted coil emboilization of ruptured intracranial aneurysms: A retrospective multicenter review.Surgical neurology international · 2012Article
- Intracranial hemorrhage following neuroendovascular procedures with abciximab is associated with high mortality: a multicenter series.Neurocritical care · 2011Article
- Prevention and treatment of thromboembolism during endovascular aneurysm therapy.Klinische Neuroradiologie · 2009Review
- Abciximab for thrombolysis during intracranial aneurysm coiling.Neuroradiology · 2008Article
- Abciximab for treatment of thromboembolic complications during endovascular coiling of intracranial aneurysms.AJNR. American journal of neuroradiology · 2008Article
- Procedural complications of coiling of ruptured intracranial aneurysms: incidence and risk factors in a consecutive series of 681 patients.AJNR. American journal of neuroradiology · 2006Article
- Platelet receptors.AJNR. American journal of neuroradiology · 2006Article
- Balloon-assisted coiling of intracranial aneurysms: evaluation of local thrombus formation and symptomatic thromboembolic complications.AJNR. American journal of neuroradiologyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeExperience with intravenous abciximab to manage thromboembolism during treatment of ruptured intracranial aneurysms is limited. We present our experience in 13 patients.
methodsWe retrospectively reviewed all patients with thromboembolic complications during endovascular management of ruptured intracranial aneurysms. Thromboembolic complications were treated with intravenous abciximab. We recorded patient and aneurysm demographics, aneurysm occlusion, drug therapy, complications, and outcomes.
resultsWorld Federation of Neurological Surgeons Grades were 1 or 2 in 11 patients (85%). Median time from diagnostic angiography to treatment was 1 day. Ten (77%) aneurysms involved the anterior or posterior communicating artery, and one each occurred in the posterior inferior cerebellar artery, middle cerebral artery, and basilar regions. Eleven aneurysms were <10 mm. Five were incompletely occluded (0%-90% treated) at the time of the complication. Thromboembolic complications were at the coil-ball/parent-artery interface in nine patients (69%). Two were associated with coil-loop prolapse; one was prophylactically treated without evidence of thromboembolism. Five patients (38%) had distal complications; one also had a proximal thrombus. All patients received an intravenous bolus of abciximab (5-10 mg in 92%) without infusion. Postprocedural recanalization was complete in eight (62%) and partial in four (31%). Eleven patients (85%) had a Glasgow Outcome Scale score of 1 at 3 months. One had a poor outcome (GOS4). One died following additional coiling after abciximab administration, though this intervention was uneventful in three others.
conclusionAbciximab completely or partially treated thromboembolic complications arising during coiling of ruptured aneurysms. Further coiling should be performed with extreme caution and needs to be decided on a patient-by-patient basis.
Indexed as
Identifiers
16091524PMC7975173W2182946358What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.