ArticleProceedings of the National Academy of Sciences of the United States of America2005
Coevolution between nonhomologous but functionally similar proteins and their conserved partners in the Legionella pathogenesis system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
- TheCurrent research in microbial sciences · 2022Article
- Characterization of the First Cultured Psychrotolerant Representative ofMicrobiology spectrum · 2021Article
- Evolutionary Dissection of the Dot/Icm System Based on Comparative Genomics of 58 Legionella Species.Genome biology and evolution · 2019Article
- More than 18,000 effectors in theProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires.Nature genetics · 2016Article
- Article
- Comparative analyses of Legionella species identifies genetic features of strains causing Legionnaires' disease.Genome biology · 2014Article
- IcmQ in the Type 4b secretion system contains an NAD+ binding domain.Structure (London, England : 1993) · 2013Article
- Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The 2.5 Å structure of the enterococcus conjugation protein TraM resembles VirB8 type IV secretion proteins.The Journal of biological chemistry · 2013Article
- Bacterial Type IV secretion systems: versatile virulence machines.Future microbiology · 2012Review
- Comparative and functional genomics of legionella identified eukaryotic like proteins as key players in host-pathogen interactions.Frontiers in microbiology · 2011Article
- Type IVB Secretion Systems of Legionella and Other Gram-Negative Bacteria.Frontiers in microbiology · 2011Article
- Analysis of the Legionella longbeachae genome and transcriptome uncovers unique strategies to cause Legionnaires' disease.PLoS genetics · 2010Article
- Virulence factors encoded by Legionella longbeachae identified on the basis of the genome sequence analysis of clinical isolate D-4968.Journal of bacteriology · 2010Article
- The Coxiella burnetii ankyrin repeat domain-containing protein family is heterogeneous, with C-terminal truncations that influence Dot/Icm-mediated secretion.Journal of bacteriology · 2009Article
- Structure and function of interacting IcmR-IcmQ domains from a type IVb secretion system in Legionella pneumophila.Structure (London, England : 1993) · 2009Article
- Comparative genomics reveal extensive transposon-mediated genomic plasticity and diversity among potential effector proteins within the genus Coxiella.Infection and immunity · 2009Article
- Coxiella type IV secretion and cellular microbiology.Current opinion in microbiology · 2009Review
- Type IV secretion systems: tools of bacterial horizontal gene transfer and virulence.Cellular microbiology · 2008Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Legionella pneumophila, the causative agent of Legionnaires' disease, and other pathogenic Legionella species multiply inside protozoa and human macrophages by using the intracellular multiplication (Icm)/defect in organelle trafficking (Dot) type-IV secretion system. The IcmQ protein, which possesses pore-forming activity, and IcmR, which regulates the IcmQ activity, are two essential components of this system. Analysis of the region expected to contain these two genes from 29 Legionella species revealed the presence of a conserved icmQ gene and a large hypervariable gene family [functional homologues of icmR (fir) genes], located at the icmR genomic position. Although hypervariable in their sequence, the fir genes from all 29 Legionella species were found, together with their corresponding icmQ genes, to function similarly during infection. In addition, all FIR proteins we examined were found to interact with their corresponding IcmQ proteins. Detailed bioinformatic, biochemical, and genetic analysis of the interaction between the variable FIR proteins and conserved IcmQ proteins revealed that their interaction depends on a variable region located between two conserved domains of IcmQ. This variable region was also found to be critical for IcmQ self-interaction, and the region probably coevolved with the corresponding FIR protein. A FIR-IcmQ pair was also found in Coxiella burnetii, the only known non-Legionella bacterium that contains an Icm/Dot system, indicating the significance of this protein pair for the function of this type-IV secretion system. We hypothesize that this gene variation, which is probably mediated by positive selection, plays an important role in the evolutionary arms race between the protozoan host cell and the pathogen.
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