ReviewCurrent HIV/AIDS reports2004
Advances in understanding immunologic control of HIV infection.
Review in Current HIV/AIDS reports, 2004. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Defective human immunodeficiency virus-specific CD8+ T-cell polyfunctionality, proliferation, and cytotoxicity are not restored by antiretroviral therapy.Journal of virology · 2009Trial
- Bispecific antibody-derived molecules to target persistent HIV infection.Journal of virus eradication · 2022Article
- Preclinical Development and Clinical-Scale Manufacturing of HIV Gag-Specific, LentivirusModified CD4 T Cells for HIV Functional Cure.Molecular therapy. Methods & clinical development · 2020Article
- Mechanisms of CD8European journal of immunology · 2018Review
- HIV-specific T-cell Responses and Generalized Activation in HIV-1 Infected Long-term Non-progressors and Progressors from South India.Current HIV research · 2018Article
- Thirty Years with HIV Infection-Nonprogression Is Still Puzzling: Lessons to Be Learned from Controllers and Long-Term Nonprogressors.AIDS research and treatment · 2012Article
- Qualitative features of the HIV-specific CD8+ T-cell response associated with immunologic control.Current opinion in HIV and AIDS · 2011Review
- Comparisons of CD8+ T cells specific for human immunodeficiency virus, hepatitis C virus, and cytomegalovirus reveal differences in frequency, immunodominance, phenotype, and interleukin-2 responsiveness.Journal of virology · 2009Article
- Lytic granule loading of CD8+ T cells is required for HIV-infected cell elimination associated with immune control.Immunity · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Over the past several years, the progress made in understanding the cellular immune response to HIV is likely greater compared to any other time since the beginning of the worldwide epidemic. This progress has largely been made possible by technical advances that have permitted a much more quantitative and highly detailed study of virus-specific cellular immunity in humans than was previously available. However, despite intensive study of the HIV-specific cellular immune response, we do not fully understand the nature of immunologic control in some rare cases and lack of control in most of untreated patients. It has become increasingly clear that HIV replication is poorly controlled in most untreated patients, despite a high-frequency HIV-specific cellular immune response. Therefore, attention has turned to qualitative features of the immune response that may dictate restriction of viral replication. Because most vaccines in preclinical or clinical testing rely on cellular immune responses that may alter disease progression but are unlikely to prevent infection, understanding these qualitative features is of particular importance. Further study could yield critical information for inducing effective immunity in vaccinees, preventing the loss of control of viral replication on the infection of vaccinees, or inducing immunologic control in infected humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.