ReviewCurrent allergy and asthma reports2005
New insights into the role of the complement pathway in allergy and asthma.
Review in Current allergy and asthma reports, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- The local complement activation on vascular bed of patients with systemic sclerosis: a hypothesis-generating study.PloS one · 2015Trial
- Vernal Keratoconjunctivitis: Immunopathological Insights and Therapeutic Applications of Immunomodulators.Life (Basel, Switzerland) · 2024Review
- Cytokines in Allergic Conjunctivitis: Unraveling Their Pathophysiological Roles.Life (Basel, Switzerland) · 2024Review
- Age-related macular degeneration and premorbid allergic diseases: a population-based case-control study.Scientific reports · 2021Article
- Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants.Environmental science & technology · 2017Article
- Complement mediators: key regulators of airway tissue remodeling in asthma.Journal of translational medicine · 2015Review
- Mesenteric lymph node transcriptome profiles in BALB/c mice sensitized to three common food allergens.BMC genomics · 2011Article
- Complement components (C3, C4) as inflammatory markers in asthma.Indian journal of pediatrics · 2010Article
- A complex role for complement in allergic asthma.Expert review of clinical immunology · 2010Review
- Regulation of human mast cell and basophil function by anaphylatoxins C3a and C5a.Immunology letters · 2010Review
- A module-based analytical strategy to identify novel disease-associated genes shows an inhibitory role for interleukin 7 Receptor in allergic inflammation.BMC systems biology · 2009Article
- Isotype and IgG subclass distribution of autoantibody response to alpha-enolase protein in adult patients with severe asthma.Yonsei medical journal · 2008Article
- Complement 5a receptor inhibition improves renal allograft survival.Journal of the American Society of Nephrology : JASN · 2008Article
- Identification of a transcriptional fingerprint of estrogen exposure in rainbow trout liver.Toxicological sciences : an official journal of the Society of Toxicology · 2008Article
- Of mice and men, revisited: new insights into an ancient molecule from studies of complement activation by Cryptococcus neoformans.Infection and immunity · 2006Article
- The role of complement in danger sensing and transmission.Immunologic research · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Despite extensive inquiry, the mechanisms underlying the pathophysiology of allergic diseases remain unknown. Recently, there has been a resurgence of interest in the role of the innate immune mediators of the complement pathway in asthma pathogenesis, particularly the anaphylatoxins (C3a, C5a). The emerging paradigm is that C3a production at the airway surface serves as a common pathway for the induction of airway hyperresponsiveness to a variety of asthma triggers (ie, allergens, viral infections, particulate matter, ozone, smoke), whereas C5/C5a plays a dual immunoregulatory role by protecting against Th2-mediated immune responses during initiation of responses and a proinflammatory role once immune responses are established. Support for a causal role for altered anaphylatoxin production in human disease comes from reports of exaggerated complement production in the lungs of asthmatics as well as the association of asthma with polymorphisms in C3/C3aR genes. Herein, we explore our current understanding of the role of complement activation in asthma pathogenesis and highlight the potential of targeting complement pathways for therapeutic drug development.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.