Evidence map›Paper›PMID 16091200›Full record

ReviewCurrent oncology reports2005

Tumor cell and circulating markers in melanoma: diagnosis, prognosis, and management.

Nicole Kounalakis, James S Goydos

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current oncology reports, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Prognostic significance of serum S100B protein in high-risk surgically resected melanoma patients participating in Intergroup Trial ECOG 1694.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2009
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Nicole KounalakisThe Cancer Institute of New Jersey, New Brunswick, NJ 08901, USA.
James S Goydos

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The search is on for biomarkers for use in the diagnosis, staging, prognosis, and management of patients with melanoma. As with many types of cancer, the hematogenous spread of melanoma is a bad prognostic sign, and many groups have attempted to detect circulating melanoma cells in patients with different stages of melanoma. Some studies have used direct extraction of intact tumor cells from the peripheral blood and others the detection of surrogate markers of circulating melanoma cells, such as tyrosinase or MART-1. However, a correlation between the detection of intact melanoma cells in the circulation and prognosis is controversial. Many other biomarkers have also been studied, including lactate dehydrogenase, S100, TA90, and C-reactive protein. Much progress has been made, and preliminary studies have shown promise with many of these markers. Finally, the detection of tumor-specific circulating DNA has shown promise as a prognostic and diagnostic marker of disease in melanoma as well. In this review we examine the most promising biomarkers for use in patients with cutaneous melanoma.

Indexed as

Biomarkers, TumorNeoplastic Cells, CirculatingAntigens, NeoplasmBiomarkersCell Line, TumorC-Reactive ProteinHumansL-Lactate DehydrogenaseLoss of HeterozygosityMART-1 AntigenMelanomaMicrosatellite RepeatsModels, BiologicalMonophenol MonooxygenaseNeoplasm ProteinsPrognosisAntigens, NeoplasmBiomarkersBiomarkers, TumorC-Reactive ProteinL-Lactate DehydrogenaseMART-1 AntigenMLANA protein, humanMonophenol MonooxygenaseNeoplasm ProteinsS100 ProteinsTA90 immune complex

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.