ArticleProceedings of the National Academy of Sciences of the United States of America2005
IL-10-dependent infectious tolerance after the treatment of experimental allergic encephalomyelitis with redirected CD4+CD25+ T lymphocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.
- The change of Th17/Treg cells and IL-10/IL-17 in Chinese children with Henoch-Schonlein purpura: A PRISMA-compliant meta-analysis.Medicine · 2019Pooled it
- Review
- Activation pathways that drive CD4Immunological reviews · 2022Review
- The emerging role of regulatory cell-based therapy in autoimmune disease.Frontiers in immunology · 2022Review
- Made to Measure: Patient-Tailored Treatment of Multiple Sclerosis Using Cell-Based Therapies.International journal of molecular sciences · 2021Review
- Emerging Therapeutics for Immune Tolerance: Tolerogenic Vaccines, T cell Therapy, and IL-2 Therapy.Frontiers in immunology · 2021Review
- Human placental trophoblast cells contribute to maternal-fetal tolerance through expressing IL-35 and mediating iTNature communications · 2019Article
- Next-generation regulatory T cell therapy.Nature reviews. Drug discovery · 2019Review
- The making and function of CAR cells.Immunology letters · 2019Review
- Functions of T-cell subsets and their related cytokines in the pathological processes of autoimmune encephalomyelitic mice.International journal of clinical and experimental pathology · 2018Article
- Clinical Applications of Regulatory T cells in Adoptive Cell Therapies.Cell & gene therapy insights · 2018Article
- MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3.Nature communications · 2015Article
- Treg cells mediate recovery from EAE by controlling effector T cell proliferation and motility in the CNS.Acta neuropathologica communications · 2014Article
- Selective immunotargeting of diabetogenic CD4 T cells by genetically redirected T cells.Immunology · 2014Article
- Transplant tolerance to pancreatic islets is initiated in the graft and sustained in the spleen.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Article
- Diversification and senescence of Foxp3+ regulatory T cells during experimental autoimmune encephalomyelitis.European journal of immunology · 2013Article
- Active suppression induced by repetitive self-epitopes protects against EAE development.PloS one · 2013Article
- The T cell response to IL-10 alters cellular dynamics and paradoxically promotes central nervous system autoimmunity.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Immunological aspects in chronic lymphocytic leukemia (CLL) development.Annals of hematology · 2012Review
- Potential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis.BMC medicine · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
How small numbers of CD4+CD25+ regulatory T cells suppress autoimmune responses in vivo is unclear. In this report we analyze the immunomodulatory activity of CD4+CD25+ T cells that are antigen-specifically redirected against myelin basic protein (MBP)89-101-specific autoreactive T cells by a MBP89-101-IA(s)-zeta chimeric receptor. We have previously shown that these redirected regulatory T cells are highly potent in treating a model autoimmune disease, experimental allergic encephalomyelitis. We show here that they have only limited effect in vivo on autoreactive T cell proliferation and therefore do not act by deleting or suppressing the expansion of pathologic effector cells. Rather, the redirected CD4+CD25+ T cells divert the pathologic T helper 1 self-specific T cell response to one characterized by high IL-10 and lower IL-4 production. Significantly, when isolated from the inducing CD4+CD25+ regulatory T cells, these self-specific T cells can independently suppress the autoreactive T cell response and experimental allergic encephalomyelitis development in an IL-10-dependent manner. These results provide evidence that CD4+CD25+ regulatory T cells can manipulate the adaptive immune response in vivo through the infectious induction of tolerance, specifically by promoting the formation of antigen-specific, IL-10-secreting regulatory T cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.