ArticleThe Journal of experimental medicine2005
Regulation of TCR delta and alpha repertoires by local and long-distance control of variable gene segment chromatin structure.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 61 citations in OpenAlex.
- Regulation of T-cell Receptor Gene Expression by Three-Dimensional Locus Conformation and Enhancer Function.International journal of molecular sciences · 2020Review
- A role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra-Tcrd locus.Nucleic acids research · 2020Article
- Blueprint of human thymopoiesis reveals molecular mechanisms of stage-specific TCR enhancer activation.The Journal of experimental medicine · 2020Article
- Epigenetic modifications of the VImmunology · 2017Article
- Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.Cell reports · 2017Article
- An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Isolation and Ex Vivo Culture of Vδ1+CD4+γδ T Cells, an Extrathymic αβT-cell Progenitor.Journal of visualized experiments : JoVE · 2015Article
- T-cell receptor α enhancer is inactivated in αβ T lymphocytes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Specification of Vδ and Vα usage by Tcra/Tcrd locus V gene segment promoters.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Long-Range Regulation of V(D)J Recombination.Advances in immunology · 2015Review
- Recent insights into the transcriptional control of the Tcra/Tcrd locus by distant enhancers during the development of T-lymphocytes.Transcription · 2015Review
- Epigenetic control of immunity.Cold Spring Harbor perspectives in biology · 2014Article
- Human Peripheral CD4(+) Vδ1(+) γδT Cells Can Develop into αβT Cells.Frontiers in immunology · 2014Article
- Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci.Journal of immunology (Baltimore, Md. : 1950) · 2013Review
- Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line.European journal of immunology · 2013Article
- Tcra gene recombination is supported by a Tcra enhancer- and CTCF-dependent chromatin hub.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Highly diverse TCRα chain repertoire of pre-immune CD8⁺ T cells reveals new insights in gene recombination.The EMBO journal · 2012Article
- Tcra enhancer activation by inducible transcription factors downstream of pre-TCR signaling.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Regulation of TCRβ allelic exclusion by gene segment proximity and accessibility.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Long-distance regulation of fetal V(δ) gene segment TRDV4 by the Tcrd enhancer.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Murine Tcrd and Tcra gene segments reside in a single genetic locus and undergo recombination in CD4- CD8- (double negative [DN]) and CD4+ CD8+ (double positive [DP]) thymocytes, respectively. TcraTcrd locus variable gene segments are subject to complex regulation. Only a small subset of approximately 100 variable gene segments contributes substantially to the adult TCRdelta repertoire. Moreover, although most contribute to the TCRalpha repertoire, variable gene segments that are Jalpha proximal are preferentially used during primary Tcra recombination. We investigate the role of local chromatin accessibility in determining the developmental pattern of TcraTcrd locus variable gene segment recombination. We find variable gene segments to be heterogeneous with respect to acetylation of histones H3 and H4. Those that dominate the adult TCRdelta repertoire are hyperacetylated in DN thymocytes, independent of their position in the locus. Moreover, proximal variable gene segments show dramatic increases in histone acetylation and germline transcription in DP thymocytes, a result of super long-distance regulation by the Tcra enhancer. Our results imply that differences in chromatin accessibility contribute to biases in TcraTcrd locus variable gene segment recombination in DN and DP thymocytes and extend the distance over which the Tcra enhancer can regulate chromatin structure to a remarkable 525 kb.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.