ArticleThe Journal of experimental medicine2005
IL-4 receptor expression on CD8+ T cells is required for the development of protective memory responses against liver stages of malaria parasites.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 77 citations in OpenAlex.
- Host candidate gene polymorphisms and associated clearance of P. falciparum amodiaquine and fansidar resistance mutants in children less than 5 years in Cameroon.Pathogens and global health · 2014Trial
- Distinct CD8iScience · 2026Article
- γδ T cell-derived IL-4 initiates CD8Nature immunology · 2026Article
- Malaria: past, present, and future.Signal transduction and targeted therapy · 2025Review
- Patients taking benralizumab, dupilumab, or mepolizumab have lower postvaccination SARS-CoV-2 immunity.The Journal of allergy and clinical immunology · 2024Observational
- Interactions with Asialo-Glycoprotein Receptors and Platelets Are Dispensable for CD8Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- ChronicAmerican journal of physiology. Heart and circulatory physiology · 2021Article
- Acute IL-4 Governs Pathogenic T Cell Responses duringImmunoHorizons · 2020Article
- TCR Signal Strength and Antigen Affinity Regulate CD8Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- T cell-mediated immunity to malaria.Nature reviews. Immunology · 2019Review
- Helminth-induced IL-4 expands bystander memory CD8Nature communications · 2018Article
- Lineage Differentiation Program of Invariant Natural Killer T Cells.Immune network · 2017Review
- Human intrahepatic CD69 + CD8+ T cells have a tissue resident memory T cell phenotype with reduced cytolytic capacity.Scientific reports · 2017Article
- Assessment of the Plasmodium falciparum Preerythrocytic Antigen UIS3 as a Potential Candidate for a Malaria Vaccine.Infection and immunity · 2017Article
- Long-term Maintenance of CD4 T Cell Memory Responses to Malaria Antigens in Malian Children Coinfected withFrontiers in immunology · 2017Article
- IL-4 sensitivity shapes the peripheral CD8+ T cell pool and response to infection.The Journal of experimental medicine · 2016Article
- Evaluation of the immunogenicity and protective efficacy of killed Leishmania donovani antigen along with different adjuvants against experimental visceral leishmaniasis.Medical microbiology and immunology · 2015Article
- From the draining lymph node to the liver: the induction and effector mechanisms of malaria-specific CD8+ T cells.Seminars in immunopathology · 2015Review
- CD40 is required for protective immunity against liver stage Plasmodium infection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Tissue signatures influence the activation of intrahepatic CD8(+) T cells against malaria sporozoites.Frontiers in microbiology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
IL-4 receptor (IL-4R)-deficient CD8+ T cells specific for the circumsporozoite protein of Plasmodium yoelii develop a severely impaired memory response after priming with parasites. Memory CD8+ T cells lacking the IL-4R are unable to establish a stable population residing in nonlymphoid organs, although they develop normally in lymphoid organs. Because memory cells from nonlymphoid organs disappear shortly after immunization, the protective antiparasitic activity of this T cell response also is lost. These results demonstrate that IL-4/IL-4R interactions on CD8+ T cells play a critical role in modulating the development and tissue distribution of memory cells induced by parasite immunization. They also indicate that memory cells residing in nonlymphoid tissues are critical for protective immunity against malaria parasites.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.