ArticleThe Journal of cell biology2005
Transcytosis of NgCAM in epithelial cells reflects differential signal recognition on the endocytic and secretory pathways.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 49 citations in OpenAlex.
- Sonic hedgehog is basolaterally sorted from the TGN and transcytosed to the apical domain involving Dispatched-1 at Rab11-ARE.Frontiers in cell and developmental biology · 2022Article
- CD13 orients the apical-basal polarity axis necessary for lumen formation.Nature communications · 2021Article
- Novel function for AP-1B during cell migration.Molecular biology of the cell · 2020Article
- Spatial control of membrane traffic in neuronal dendrites.Molecular and cellular neurosciences · 2020Review
- Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting.Journal of cell science · 2019Article
- Defective Transcytosis of APP and Lipoproteins in Human iPSC-Derived Neurons with Familial Alzheimer's Disease Mutations.Cell reports · 2016Article
- Significance of transcytosis in Alzheimer's disease: BACE1 takes the scenic route to axons.BioEssays : news and reviews in molecular, cellular and developmental biology · 2015Article
- Adaptor proteins involved in polarized sorting.The Journal of cell biology · 2014Review
- Mutation conferring apical-targeting motif on AE1 exchanger causes autosomal dominant distal RTA.Journal of the American Society of Nephrology : JASN · 2012Article
- Cellular prion protein participates in amyloid-β transcytosis across the blood-brain barrier.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2012Article
- Assembly and maintenance of nodes of ranvier rely on distinct sources of proteins and targeting mechanisms.Neuron · 2012Article
- The role of secretory and endocytic pathways in the maintenance of cell polarity.Essays in biochemistry · 2012Review
- Mechanisms of polarized membrane trafficking in neurons -- focusing in on endosomes.Molecular and cellular neurosciences · 2011Review
- Arf6 regulates AP-1B-dependent sorting in polarized epithelial cells.The Journal of cell biology · 2011Article
- ARH cooperates with AP-1B in the exocytosis of LDLR in polarized epithelial cells.The Journal of cell biology · 2011Article
- Trafficking guidance receptors.Cold Spring Harbor perspectives in biology · 2010Review
- Phosphatidylinositol 3,4,5-trisphosphate localization in recycling endosomes is necessary for AP-1B-dependent sorting in polarized epithelial cells.Molecular biology of the cell · 2010Article
- Axonal targeting of Trk receptors via transcytosis regulates sensitivity to neurotrophin responses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Rab8 regulates basolateral secretory, but not recycling, traffic at the recycling endosome.Molecular biology of the cell · 2008Article
- Recycling endosomes of polarized epithelial cells actively sort apical and basolateral cargos into separate subdomains.Molecular biology of the cell · 2007Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
NgCAM is a cell adhesion molecule that is largely axonal in neurons and apical in epithelia. In Madin-Darby canine kidney cells, NgCAM is targeted to the apical surface by transcytosis, being first inserted into the basolateral domain from which it is internalized and transported to the apical domain. Initial basolateral transport is mediated by a sequence motif (Y(33)RSL) decoded by the AP-1B clathrin adaptor complex. This motif is a substrate in vitro for tyrosine phosphorylation by p60src, a modification that disrupts NgCAM's ability to interact with clathrin adaptors. Based on the behavior of various NgCAM mutants, it appears that after arrival at the basolateral surface, the AP-1B interaction site is silenced by phosphorylation of Tyr(33). This slows endocytosis and inhibits basolateral recycling from endosomes, resulting in NgCAM transcytosis due to a cryptic apical targeting signal in its extracellular domain. Thus, transcytosis of NgCAM and perhaps other membrane proteins may reflect the spatial regulation of recognition by adaptors such as AP-1B.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.