ArticleThe Journal of cell biology2005
The origin recognition core complex regulates dendrite and spine development in postmitotic neurons.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 61 citations in OpenAlex.
- p120-catenin subfamily members have distinct as well as shared effects on dendrite morphology during neuron developmentFrontiers in cellular neuroscience · 2023Article
- Article
- Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma.Journal of Cancer · 2020Article
- The Susceptibility of Retinal Ganglion Cells to Glutamatergic Excitotoxicity Is Type-Specific.Frontiers in neuroscience · 2019Article
- Nonreplicative functions of the origin recognition complex.Nucleus (Austin, Tex.) · 2018Review
- Glutamate Activity Regulates and Dendritic Development of J-RGCs.Frontiers in cellular neuroscience · 2018Article
- The effects of immune protein CD3ζ development and degeneration of retinal neurons after optic nerve injury.PloS one · 2017Article
- ORC proteins in the mammalian zygote.Cell and tissue research · 2016Review
- Prion-induced neurotoxicity: Possible role for cell cycle activity and DNA damage response.World journal of virology · 2015Review
- Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's disease.Acta neuropathologica · 2015Review
- A general principle governs vision-dependent dendritic patterning of retinal ganglion cells.The Journal of comparative neurology · 2014Article
- Pro-brain-derived neurotrophic factor inhibits GABAergic neurotransmission by activating endocytosis and repression of GABAA receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits.Journal of neurochemistry · 2014Article
- Cell-intrinsic drivers of dendrite morphogenesis.Development (Cambridge, England) · 2013Review
- Post-mitotic role of the cell cycle machinery.Current opinion in cell biology · 2013Review
- Transmission disequilibrium of small CNVs in simplex autism.American journal of human genetics · 2013Article
- Proteostasis in complex dendrites.Nature reviews. Neuroscience · 2013Review
- The origin recognition complex in human diseases.Bioscience reports · 2013Review
- Meier-Gorlin syndrome mutations disrupt an Orc1 CDK inhibitory domain and cause centrosome reduplication.Genes & development · 2012Article
- Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization.Cell research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The origin recognition complex (ORC) ensures exactly one round of genome replication per cell cycle through acting as a molecular switch that precisely controls the assembly, firing, and inactivation of the replication initiation machinery. Recent data indicate that it may also coordinate the processes of mitosis and cytokinesis and ensure the proper distribution of replicated genome to daughter cells. We have found that the ORC core subunits are highly expressed in the nervous system. They are selectively localized to the neuronal somatodendritic compartment and enriched in the membrane fraction. siRNA knockdown of ORC subunits dramatically reduced dendritic branch formation and severely impeded dendritic spine emergence. Expression of ORC ATPase motif mutants enhanced the branching of dendritic arbors. The ORC core complex thus appears to have a novel role in regulating dendrite and dendritic spine development in postmitotic neurons.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.