ArticleGenome biology2005
Evolution of selenium utilization traits.
Article in Genome biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 97 citations in OpenAlex.
- Tolerance to heavy metals of bacteria from Brazilian deep aquatic environments.Archives of microbiology · 2026Article
- deep-Sep: a deep learning-based method for fast and accurate prediction of selenoprotein genes in bacteria.mSystems · 2025Article
- Recoding UAG to selenocysteine inRNA (New York, N.Y.) · 2023Article
- Pan-Genome Analysis Reveals Host-Specific Functional Divergences inMicroorganisms · 2021Article
- Exploring the selenium-over-sulfur substrate specificity and kinetics of a bacterial selenocysteine lyase.Biochimie · 2021Article
- Macrophage Selenoproteins Restrict Intracellular Replication ofFrontiers in immunology · 2021Article
- Bioinformatics of Selenoproteins.Antioxidants & redox signaling · 2020Review
- Comparative genomic analysis of selenium utilization traits in different marine environments.Journal of microbiology (Seoul, Korea) · 2020Article
- Role of Selenoproteins in Bacterial Pathogenesis.Biological trace element research · 2019Review
- Horizontal acquisition of hydrogen conversion ability and other habitat adaptations in the Hydrogenovibrio strains SP-41 and XCL-2.BMC genomics · 2019Article
- Evolution, regulation, and function of porcine selenogenome.Free radical biology & medicine · 2018Review
- Comparison of the redox chemistry of sulfur- and selenium-containing analogs of uracil.Free radical biology & medicine · 2017Article
- Lokiarchaeota Marks the Transition between the Archaeal and Eukaryotic Selenocysteine Encoding Systems.Molecular biology and evolution · 2016Article
- A novel uncultured heterotrophic bacterial associate of the cyanobacterium Moorea producens JHB.BMC microbiology · 2016Article
- Comparative genomics reveals new evolutionary and ecological patterns of selenium utilization in bacteria.The ISME journal · 2016Article
- Comparative Single-Cell Genomics of Chloroflexi from the Okinawa Trough Deep-Subsurface Biosphere.Applied and environmental microbiology · 2016Article
- Genome Analysis of Planctomycetes Inhabiting Blades of the Red Alga Porphyra umbilicalis.PloS one · 2016Article
- Evolution of the Selenoproteome in Helicobacter pylori and Epsilonproteobacteria.Genome biology and evolution · 2015Article
- Evolution of selenophosphate synthetases: emergence and relocation of function through independent duplications and recurrent subfunctionalization.Genome research · 2015Article
- The evolutionary and functional diversity of classical and lesser-known cytoplasmic and organellar translational GTPases across the tree of life.BMC genomics · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThe essential trace element selenium is used in a wide variety of biological processes. Selenocysteine (Sec), the 21st amino acid, is co-translationally incorporated into a restricted set of proteins. It is encoded by an UGA codon with the help of tRNASec (SelC), Sec-specific elongation factor (SelB) and a cis-acting mRNA structure (SECIS element). In addition, Sec synthase (SelA) and selenophosphate synthetase (SelD) are involved in the biosynthesis of Sec on the tRNASec. Selenium is also found in the form of 2-selenouridine, a modified base present in the wobble position of certain tRNAs, whose synthesis is catalyzed by YbbB using selenophosphate as a precursor.
resultsWe analyzed completely sequenced genomes for occurrence of the selA, B, C, D and ybbB genes. We found that selB and selC are gene signatures for the Sec-decoding trait. However, selD is also present in organisms that do not utilize Sec, and shows association with either selA, B, C and/or ybbB. Thus, selD defines the overall selenium utilization. A global species map of Sec-decoding and 2-selenouridine synthesis traits is provided based on the presence/absence pattern of selenium-utilization genes. The phylogenies of these genes were inferred and compared to organismal phylogenies, which identified horizontal gene transfer (HGT) events involving both traits.
conclusionThese results provide evidence for the ancient origin of these traits, their independent maintenance, and a highly dynamic evolutionary process that can be explained as the result of speciation, differential gene loss and HGT. The latter demonstrated that the loss of these traits is not irreversible as previously thought.
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