ArticleImmunogenetics2005
Serological and molecular diversity in the cattle MHC class I region.
Article in Immunogenetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- A new method for ecologists to estimate heterozygote excess and deficit for multi-locus gene families.Ecology and evolution · 2024Article
- Granzyme B Is an Essential Mediator in CD8Infection and immunity · 2019Article
- Improved Prediction of Bovine Leucocyte Antigens (BoLA) Presented Ligands by Use of Mass-Spectrometry-Determined Ligand and in Vitro Binding Data.Journal of proteome research · 2018Article
- Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing.Immunogenetics · 2016Article
- Article
- Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K.Immunogenetics · 2013Article
- Theileria annulata-transformed cell lines are efficient antigen-presenting cells for in vitro analysis of CD8 T cell responses to bovine herpesvirus-1.Veterinary research · 2011Article
- Extensive polymorphism and evidence of immune selection in a highly dominant antigen recognized by bovine CD8 T cells specific for Theileria annulata.Infection and immunity · 2011Article
- 454 sequencing reveals extreme complexity of the class II Major Histocompatibility Complex in the collared flycatcher.BMC evolutionary biology · 2010Article
- Analysis of MHC class I genes across horse MHC haplotypes.Immunogenetics · 2010Article
- CD8+ T-cell responses to Theileria parva are preferentially directed to a single dominant antigen: Implications for parasite strain-specific immunity.European journal of immunology · 2009Article
- Demonstration of strain-specific CD8 T cell responses to Theileria annulata.Parasite immunology · 2008Article
- Characterization of the fine specificity of bovine CD8 T-cell responses to defined antigens from the protozoan parasite Theileria parva.Infection and immunity · 2008Article
- The origins of polypeptide domains.BioEssays : news and reviews in molecular, cellular and developmental biology · 2007Review
- Generation and maintenance of diversity in the cattle MHC class I region.Immunogenetics · 2006Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Information on major histocompatibility complex (MHC) diversity in cattle is important to aid our understanding of immune responses and may contribute to maintenance of healthy cattle populations. Equally, understanding the mechanisms involved in generating this diversity may shed light on the complex nature of mammalian MHC evolution. The aim of this study was to assess molecular and serological variation within cattle MHC class I molecules and to study the mechanisms generating diversity. To address this aim, sequence variation was examined in 12 serologically assigned alleles from three putative loci and correlated with monoclonal antibody (mAb) binding data. The results demonstrate that both alloantisera and mAbs often fail to distinguish gene products that differ by a significant number of amino acids. Conversely, some mAbs could distinguish alleles differing by only one or two amino acids. Examination of the sequences demonstrates sharing of motifs between alleles, some encoded at distinct loci, supporting the occurrence of interlocus recombination within the cattle MHC class I region. The implications of this for MHC sequence diversity, and functional capability, are discussed.
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