ArticleBiophysical journal2005
Distinguishing modes of eukaryotic gradient sensing.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Emergent eukaryotic directional sensing via receptor degradation and diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Dynamics phenotyping across length and time scales in collective cell migration.Seminars in cell & developmental biology · 2019Review
- Review
- Multi-phasic bi-directional chemotactic responses of the growth cone.Scientific reports · 2016Article
- Phase geometries of two-dimensional excitable waves govern self-organized morphodynamics of amoeboid cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A bistable model of cell polarity.PloS one · 2012Article
- How cells integrate complex stimuli: the effect of feedback from phosphoinositides and cell shape on cell polarization and motility.PLoS computational biology · 2012Article
- Mathematical analysis of steady-state solutions in compartment and continuum models of cell polarization.Mathematical biosciences and engineering : MBE · 2011Article
- A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.PLoS computational biology · 2011Review
- Reaction-diffusion systems in intracellular molecular transport and control.Angewandte Chemie (International ed. in English) · 2010Review
- Directional persistence of cell migration coincides with stability of asymmetric intracellular signaling.Biophysical journal · 2010Article
- Cell stimulation with optically manipulated microsources.Nature methods · 2009Article
- Bayesian model predicts the response of axons to molecular gradients.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Calling heads from tails: the role of mathematical modeling in understanding cell polarization.Current opinion in cell biology · 2009Review
- Receptor noise limitations on chemotactic sensing.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Accuracy of direct gradient sensing by single cells.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Modeling robustness tradeoffs in yeast cell polarization induced by spatial gradients.PloS one · 2008Article
- Directional sensing during chemotaxis.FEBS letters · 2008Review
- Wave-pinning and cell polarity from a bistable reaction-diffusion system.Biophysical journal · 2008Article
- Bias in the gradient-sensing response of chemotactic cells.Journal of theoretical biology · 2007Article
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Authors and funding
3 authors.
Funding
Abstract
We develop a mathematical model of phosphoinositide-mediated gradient sensing that can be applied to chemotactic behavior in highly motile eukaryotic cells such as Dictyostelium and neutrophils. We generate four variants of our model by adjusting parameters that control the strengths of coupled positive feedbacks and the importance of molecules that translocate from the cytosol to the membrane. Each variant exhibits a qualitatively different mode of gradient sensing. Simulations of characteristic behaviors suggest that differences between the variants are most evident at transitions between efficient gradient detection and failure. Based on these results, we propose criteria to distinguish between possible modes of gradient sensing in real cells, where many biochemical parameters may be unknown. We also identify constraints on parameters required for efficient gradient detection. Finally, our analysis suggests how a cell might transition between responsiveness and nonresponsiveness, and between different modes of gradient sensing, by adjusting its biochemical parameters.
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