ArticleBiophysical journal2005
Diffusion of cholesterol and its precursors in lipid membranes studied by 1H pulsed field gradient magic angle spinning NMR.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Article
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- Effects of a Polarizable Force Field on Membrane Dynamics: Surface Viscosity, Lipid Diffusion, and Peptide Induced Pore Formation.Journal of computational chemistry · 2025Article
- Influence of the Water Model on the Structure and Interactions of the GPR40 Protein with the Lipid Membrane and the Solvent: Rigid versus Flexible Water Models.Journal of chemical theory and computation · 2024Article
- The Chemical Reactivity of Membrane Lipids.Chemical reviews · 2024Review
- Temperature-Induced Restructuring of Mycolic Acid Bilayers Modeling theMolecules (Basel, Switzerland) · 2024Article
- Cholesterol, Eukaryotic Lipid Domains, and an Evolutionary Perspective of Transmembrane Signaling.Cold Spring Harbor perspectives in biology · 2023Review
- Drude Polarizable Lipid Force Field with Explicit Treatment of Long-Range Dispersion: Parametrization and Validation for Saturated and Monounsaturated Zwitterionic Lipids.Journal of chemical theory and computation · 2023Article
- Kinetic relaxation of giant vesicles validates diffusional softening in a binary lipid mixture.Physical review. E · 2023Article
- Biophysical studies of lipid nanodomains using different physical characterization techniques.Biophysical journal · 2023Review
- Special issue for Klaus Gawrisch.Biophysical journal · 2023Article
- CHARMM36 Lipid Force Field with Explicit Treatment of Long-Range Dispersion: Parametrization and Validation for Phosphatidylethanolamine, Phosphatidylglycerol, and Ether Lipids.Journal of chemical theory and computation · 2021Article
- Atomistic Molecular Dynamics Simulations of Propofol and Fentanyl in Phosphatidylcholine Lipid Bilayers.ACS omega · 2020Article
- Viscosity Landscape of Phase-Separated Lipid Membrane Estimated from Fluid Velocity Field.Biophysical journal · 2020Article
- Spontaneous Membrane Nanodomain Formation in the Absence or Presence of the Neurotransmitter Serotonin.Frontiers in cell and developmental biology · 2020Article
- Toward a Membrane-Centric Biology.Frontiers in immunology · 2020Article
- Surface Shear Viscosity and Interleaflet Friction from Nonequilibrium Simulations of Lipid Bilayers.Journal of chemical theory and computation · 2019Article
- Parameterization of a coarse-grained model of cholesterol with point-dipole electrostatics.Journal of computer-aided molecular design · 2018Article
- Drude Polarizable Force Field for Molecular Dynamics Simulations of Saturated and Unsaturated Zwitterionic Lipids.Journal of chemical theory and computation · 2017Article
- Lipid and Peptide Diffusion in Bilayers: The Saffman-Delbrück Model and Periodic Boundary Conditions.The journal of physical chemistry. B · 2017Article
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3 authors.
Funding
Abstract
Cholesterol content is critical for membrane functional properties. We studied the influence of cholesterol and its precursors desmosterol and lanosterol on lateral diffusion of phospholipids and sterols by1H pulsed field gradients (PFG) magic angle spinning (MAS) NMR spectroscopy. The high resolution of resonances afforded by MAS NMR permitted simultaneous diffusion measurements on 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) and sterols. The cholesterol diffusion mirrored the DPPC behavior, but rates were slightly higher at all cholesterol concentrations. DPPC and cholesterol diffusion rates decreased and became cholesterol concentration dependent with the onset of liquid-ordered phase formation. The activation energies of diffusion in the coexistence region of liquid-ordered/liquid-disordered phases are higher by about a factor of 2 compared to pure DPPC and to the pure liquid-ordered state formed at higher cholesterol concentrations. We assume that the higher activation energies are a reflection of lipid diffusion across domain boundaries. In lanosterol- and desmosterol-containing membranes, the DPPC and sterol diffusion coefficients are somewhat higher. Whereas the desmosterol rates are only slightly higher than those of DPPC, the lanosterol diffusion rates significantly exceed DPPC rates, indicating a weaker interaction between DPPC and lanosterol.
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