ArticleGenetics2005
Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 32 citations in OpenAlex.
- A Genetic Screen Links the Disease-Associated Nab2 RNA-Binding Protein to the Planar Cell Polarity Pathway inG3 (Bethesda, Md.) · 2020Article
- Article
- Identification of Proteins Required for Precise Positioning of Apc2 in Dendrites.G3 (Bethesda, Md.) · 2018Article
- Review
- Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2018Article
- Wnt Signalosome Assembly by DEP Domain Swapping of Dishevelled.Molecular cell · 2016Article
- Genome-Wide Analysis Reveals Novel Regulators of Growth in Drosophila melanogaster.PLoS genetics · 2016Article
- Outbred genome sequencing and CRISPR/Cas9 gene editing in butterflies.Nature communications · 2015Article
- Article
- Frizzled and LRP5/6 receptors for Wnt/β-catenin signaling.Cold Spring Harbor perspectives in biology · 2012Review
- Planar cell polarity controls directional Notch signaling in the Drosophila leg.Development (Cambridge, England) · 2012Article
- Wnt signaling in mammalian development: lessons from mouse genetics.Cold Spring Harbor perspectives in biology · 2012Review
- Wnt/β-catenin signaling requires interaction of the Dishevelled DEP domain and C terminus with a discontinuous motif in Frizzled.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Roles of planar cell polarity pathways in the development of neural [correction of neutral] tube defects.Journal of biomedical science · 2011Review
- Wnt pathway antagonists and angiogenesis.Protein & cell · 2010Review
- Lysine conservation and context in TGFbeta and Wnt signaling suggest new targets and general themes for posttranslational modification.Journal of molecular evolution · 2008Article
- Planar cell polarity signaling: from fly development to human disease.Annual review of genetics · 2008Review
- Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions.Development (Cambridge, England) · 2008Article
- Article
- The role of the cysteine-rich domain of Frizzled in Wingless-Armadillo signaling.The EMBO journal · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The frizzled (fz) gene in Drosophila controls two distinct signaling pathways: it directs the planar cell polarization (PCP) of epithelia and it regulates cell fate decisions through Armadillo (Arm) by acting as a receptor for the Wnt protein Wingless (Wg). With the exception of dishevelled (dsh), the genes functioning in these two pathways are distinct. We have taken a genetic approach, based on a series of new and existing fz alleles, for identifying individual amino acids required for PCP or Arm signaling. For each allele, we have attempted to quantify the strength of signaling by phenotypic measurements. For PCP signaling, the defect was measured by counting the number of cells secreting multiple hairs in the wing. We then examined each allele for its ability to participate in Arm signaling by the rescue of fz mutant embryos with maternally provided fz function. For both PCP and Arm signaling we observed a broad range of phenotypes, but for every allele there is a strong correlation between its phenotypic strength in each pathway. Therefore, even though the PCP and Arm signaling pathways are genetically distinct, the set of signaling-defective fz alleles affected both pathways to a similar extent. This suggests that fz controls these two different signaling activities by a common mechanism. In addition, this screen yielded a set of missense mutations that identify amino acids specifically required for fz signaling function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.