ArticleNeuroscience letters2005
Integration of engrafted Schwann cells into injured peripheral nerve: axonal association and nodal formation on regenerated axons.
Article in Neuroscience letters, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- Schwann-like cell conditioned medium promotes angiogenesis and nerve regeneration.Cell and tissue banking · 2022Article
- Nerve grafting for peripheral nerve injuries with extended defect sizes.Wiener medizinische Wochenschrift (1946) · 2019Review
- Cauda equina repair in the rat: Part 3. Axonal regeneration across Schwann cell-Seeded collagen foam.Muscle & nerve · 2018Article
- Characterization and Schwann Cell Seeding of up to 15.0 cm Long Spider Silk Nerve Conduits for Reconstruction of Peripheral Nerve Defects.Journal of functional biomaterials · 2016Article
- Platelet-derived growth factors-BB and fibroblast growth factors-base induced proliferation of Schwann cells in a 3D environment.Neurochemical research · 2013Article
- N-linked glycosylation supports cross-talk between receptor tyrosine kinases and androgen receptor.PloS one · 2013Article
- Intravenous transplantation of mesenchymal stromal cells to enhance peripheral nerve regeneration.BioMed research international · 2013Article
- C3 peptide promotes axonal regeneration and functional motor recovery after peripheral nerve injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Article
- Schwann cell metabolic activity in various short-term holding conditions: implications for improved nerve graft viability.International journal of otolaryngology · 2012Article
- Spider silk constructs enhance axonal regeneration and remyelination in long nerve defects in sheep.PloS one · 2011Article
- Schwann cells - a new hope in tissue engineered urinary bladder innervation. A method of cell isolation.Central European journal of urology · 2011Article
- Peripheral nerve regeneration: a current perspective.Eplasty · 2009Article
- Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells.Brain research · 2006Article
- Use of spider silk fibres as an innovative material in a biocompatible artificial nerve conduit.Journal of cellular and molecular medicineArticle
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Transplantation of myelin-forming cells can remyelinate axons, but little is known of the sodium channel organization of axons myelinated by donor cells. Sciatic nerve axons of female wild type mice were transected by a crush injury and Schwann cells (SCs) from green fluorescence protein (GFP)-expressing male mice were transplanted adjacent to the crush site. The male donor cells were identified by GFP fluorescence and fluorescence in situ hybridization (FISH) for Y chromosome. In nerves of GFP-expressing mice, GFP was observed in the axoplasm and in the cytoplasmic compartments of the Schwann cells, but not in the myelin. Following transplantation of GFP-SCs into crushed nerve of wild type mice, immuno-electron microscopic analysis indicated that GFP was observed in the cytoplasmic compartments of engrafted Schwann cells which formed myelin. Nodal and paranodal regions of the axons myelinated by the GFP-SCs were identified by Na(v)1.6 sodium channel and Caspr immunostaining, respectively. Nuclear identification of the Y chromosome by FISH confirmed the donor origin of the myelin-forming cells. These results indicate that engrafted GFP-SCs participate in myelination of regenerated peripheral nerve fibers and that Na(v)1.6 sodium channel, which is the dominant sodium channel at normal nodes, is reconstituted on the regenerated axons.
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Registered trials
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