ArticleThe Journal of allergy and clinical immunology2005
Duration of postviral airway hyperresponsiveness in children with asthma: effect of atopy.
Article in The Journal of allergy and clinical immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 84 citations in OpenAlex.
- Relationship between pediatric asthma and respiratory microbiota, intestinal microbiota: a narrative review.Frontiers in microbiology · 2025Review
- Postinfectious Pulmonary Complications: Establishing Research Priorities to Advance the Field: An Official American Thoracic Society Workshop Report.Annals of the American Thoracic Society · 2024Review
- Assessment of lung function variability documents airflow limitation in many patients with long covid.Heliyon · 2024Article
- Utility of biomarkers in the diagnosis and monitoring of asthmatic children.The World Allergy Organization journal · 2023Review
- Allergic Asthma in the Era of Personalized Medicine.Journal of personalized medicine · 2022Review
- COVID-19 Infections and Asthma.The journal of allergy and clinical immunology. In practice · 2022Article
- A Current Perspective of Allergic Asthma: From Mechanisms to Management.Handbook of experimental pharmacology · 2022Review
- YAP1, targeted by miR-375, enhanced the pro-angiogenesis of airway smooth muscle cells in asthma via STAT3 activation.Cell cycle (Georgetown, Tex.) · 2020Article
- [Clinical features of influenza with plastic bronchitis in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2020Article
- Asthma: A Loss of Post-natal Homeostatic Control of Airways Smooth Muscle With Regression Toward a Pre-natal State.Frontiers in pediatrics · 2020Review
- Rhinovirus Species-Specific Antibodies Differentially Reflect Clinical Outcomes in Health and Asthma.American journal of respiratory and critical care medicine · 2018Article
- Modulation of airway hyperresponsiveness by rhinovirus exposure.Respiratory research · 2018Review
- [Biologics in Rhinology - Forthcoming Personalized Concepts: the Future Starts Today].Laryngo- rhino- otologie · 2018Review
- Increased risk of severe vaso-occlusive episodes after initial acute chest syndrome in children with sickle cell anemia less than 4 years old: Sleep and asthma cohort.American journal of hematology · 2015Observational
- Association between inflammatory airway disease of horses and exposure to respiratory viruses: a case control study.Multidisciplinary respiratory medicine · 2015Article
- Intermittent and episode-driven use of pranlukast to reduce the frequency of wheezing in atopic children: a randomized, double-blind, placebo-controlled trial.The World Allergy Organization journal · 2015Article
- Assessment of airflow limitation, airway inflammation, and symptoms during virus-induced wheezing episodes in 4- to 6-year-old children.The Journal of allergy and clinical immunology · 2013Article
- Recurrent plastic bronchitis in a child with 2009 influenza A (H1N1) and influenza B virus infection.Journal of Korean medical science · 2012Article
- International consensus on (ICON) pediatric asthma.Allergy · 2012Article
- Viral asthma: implications for clinical practice.Journal of asthma and allergy · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRespiratory viruses induce asthma exacerbations and airway hyperresponsiveness (AHR). Atopy is an important risk factor for asthma persistence.
objectiveWe sought to evaluate whether atopy is a risk factor for prolonged AHR after upper respiratory tract infections (URIs).
methodsTwenty-five children (13 atopic and 12 nonatopic children) with intermittent virus-induced asthma were studied. Clinical evaluation, skin prick tests, methacholine bronchoprovocation, questionnaires, and a nasal wash specimen were obtained at baseline. For 9 months, subjects completed diary cards with respiratory symptoms. During their first reported cold, a nasal wash specimen was obtained. Methacholine provocation was performed 10 days and 5, 7, 9, and 11 weeks later. In case a new cold developed, the provocation schedule was followed from the beginning.
resultsViruses were detected in 17 (68%) of 25 patients during their first cold, with rhinovirus being most commonly identified (82%). AHR increased significantly 10 days after the URI, equally in both groups (P = .67), and remained so up to the fifth week. Duration of AHR in subjects experiencing a single URI ranged from 5 to 11 weeks, without a significant difference between groups. In the duration of the study, atopic children experienced more colds and asthma exacerbations than nonatopic children. Thus for duration of AHR, significant prolongation was noted in the atopic group when assessed cumulatively.
conclusionIn asthmatic children the duration of AHR after a single natural cold is 5 to 11 weeks. However, an increased rate of symptomatic cold and asthma episodes in atopic children is associated with considerable cumulative prolongation of AHR, which might help explain the role of atopy as a risk factor for asthma persistence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.