ArticleJournal of clinical microbiology2005
Pathogen evolution in vivo: genome dynamics of two isolates obtained 9 years apart from a duodenal ulcer patient infected with a single Helicobacter pylori strain.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Helicobacter pylori genomic microevolution during naturally occurring transmission between adults.PloS one · 2013Trial
- Diversification of theFrontiers in microbiology · 2016Article
- Structural analysis of hypothetical proteins from Helicobacter pylori: an approach to estimate functions of unknown or hypothetical proteins.International journal of molecular sciences · 2012Review
- Phenotypic and genotypic characterization of Stenotrophomonas maltophilia isolates from patients with cystic fibrosis: genome diversity, biofilm formation, and virulence.BMC microbiology · 2011Article
- Genomes of two chronological isolates (Helicobacter pylori 2017 and 2018) of the West African Helicobacter pylori strain 908 obtained from a single patient.Journal of bacteriology · 2011Article
- Concurrent proinflammatory and apoptotic activity of a Helicobacter pylori protein (HP986) points to its role in chronic persistence.PloS one · 2011Article
- Replicative genomics can help Helicobacter fraternity usher in good times.Gut pathogens · 2010Article
- Genome of Helicobacter pylori strain 908.Journal of bacteriology · 2010Article
- Helicobacter pylori--a seasoned pathogen by any other name.Gut pathogens · 2009Article
- Helicobacter urease: niche construction at the single molecule level.Journal of biosciences · 2009Article
- A flood of microbial genomes-do we need more?PloS one · 2009Article
- Novel protein antigen (JHP940) from the genomic plasticity region of Helicobacter pylori induces tumor necrosis factor alpha and interleukin-8 secretion by human macrophages.Journal of bacteriology · 2008Article
- Article
- Lipopolysaccharide diversity evolving in Helicobacter pylori communities through genetic modifications in fucosyltransferases.PloS one · 2008Article
- Microevolution of Helicobacter pylori type IV secretion systems in an ulcer disease patient over a ten-year period.Journal of clinical microbiology · 2007Article
- Ancestral European roots of Helicobacter pylori in India.BMC genomics · 2007Article
- Clinical and environmental Burkholderia strains: biofilm production and intracellular survival.Current microbiology · 2007Article
- Genetic analysis of Helicobacter pylori strain populations colonizing the stomach at different times postinfection.Journal of bacteriology · 2007Article
- The co-evolved Helicobacter pylori and gastric cancer: trinity of bacterial virulence, host susceptibility and lifestyle.Infectious agents and cancer · 2007Article
- Genomes of Helicobacter pylori from native Peruvians suggest admixture of ancestral and modern lineages and reveal a western type cag-pathogenicity island.BMC genomics · 2006Article
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6 authors.
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Abstract
The survival and microevolution of Helicobacter pylori strains in the niches of the stomach after eradication therapy have largely been unexplored. We analyzed genomic signatures for two successive isolates obtained 9 years apart from a duodenal ulcer patient who underwent eradication therapy for H. pylori. These isolates were genotyped based on 50 different parameters involving three different fingerprinting approaches and several evolutionarily significant and virulence-associated landmarks in the genome, including nine informative gene loci, the cag pathogenicity island and its right junction, members of the plasticity region cluster, and vacA and iceA alleles. Our observations reveal that the two isolates were derived from the same strain that colonized the patient for almost a decade and were almost identical. Microevolution, however, was observed in the cagA gene and its right junction, the vacA m1 allele, and a member of the plasticity region cluster (JHP926). These results suggest that H. pylori has a great ability to survive and reemerge as a microevolved strain posteradication, thereby hinting at the requirement for follow-up of patients after therapy.
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