ArticleJournal of clinical microbiology2005
Identification of four fimbria-encoding genomic islands that are highly specific for verocytotoxin-producing Escherichia coli serotype O157 strains.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Genomic island-encoded regulatory proteins in enterohemorrhagicVirulence · 2024Review
- Biofilm-Forming Abilities of Shiga Toxin-Producing Escherichia coli Isolates Associated with Human Infections.Applied and environmental microbiology · 2015Article
- Comparative genomics of enterohemorrhagic Escherichia coli O145:H28 demonstrates a common evolutionary lineage with Escherichia coli O157:H7.BMC genomics · 2014Article
- Novel repressor of Escherichia coli O157:H7 motility encoded in the putative fimbrial cluster OI-1.Journal of bacteriology · 2012Article
- Genomic anatomy of Escherichia coli O157:H7 outbreaks.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Genome organization of epidemic Acinetobacter baumannii strains.BMC microbiology · 2011Article
- OI-57, a genomic island of Escherichia coli O157, is present in other seropathotypes of Shiga toxin-producing E. coli associated with severe human disease.Infection and immunity · 2010Article
- Sequential translocation of an Escherchia coli two-partner secretion pathway exoprotein across the inner and outer membranes.Molecular microbiology · 2010Article
- Two distinct groups of porcine enteropathogenic Escherichia coli strains of serogroup O45 are revealed by comparative genomic hybridization and virulence gene microarray.BMC genomics · 2009Article
- Rapid determination of Escherichia coli O157:H7 lineage types and molecular subtypes by using comparative genomic fingerprinting.Applied and environmental microbiology · 2008Article
- Molecular analysis as an aid to assess the public health risk of non-O157 Shiga toxin-producing Escherichia coli strains.Applied and environmental microbiology · 2008Article
- Isolation and genetic characterization of a coinfection of non-O157 Shiga toxin-producing Escherichia coli.Journal of clinical microbiology · 2007Article
- Characterization of a novel two-partner secretion system in Escherichia coli O157:H7.Journal of bacteriology · 2007Article
- Stolbur phytoplasma genome survey achieved using a suppression subtractive hybridization approach with high specificity.Applied and environmental microbiology · 2006Article
- Use of the espZ gene encoded in the locus of enterocyte effacement for molecular typing of shiga toxin-producing Escherichia coli.Journal of clinical microbiology · 2006Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Verocytotoxin-producing Escherichia coli causes zoonotic food- or waterborne infection that may be associated with massive outbreaks and with the serious complication of hemolytic uremic syndrome (HUS). Serotypes O157:H7 and O157:NM are more commonly associated with HUS and outbreaks than other serotypes, such as O26:H11. To determine whether a genetic basis exists for why serotype O157:H7/NM causes HUS and outbreaks more often than other serotypes, such as O26:H11, we conducted suppression subtractive hybridization (SSH) between the genomes of the sequenced O157:H7 strain EDL933 and CL1, a clinical serotype O26:H11 isolate. Genes from four EDL933 fimbria-encoding genomic O islands (OIs) (OI-1, -47, -141, and -154) were identified in the SSH library. OI-47 encodes several additional putative virulence factors, including secreted and signaling proteins, a hemolysin locus, a lipoprotein, an ABC transport system, and a lipid biosynthesis locus. The distribution of the OIs was investigated by PCR and Southern hybridization (when PCR was negative) with 69 VTEC strains belonging to 39 different serotypes corresponding to 5 seropathotypes that differ in their disease and epidemic potential. The four OIs described here were distributed almost exclusively in serotypes O157:H7 and O157:NM, which indicates that they may be associated with the ability of these strains to colonize human and/or animal intestinal tracts and to cause epidemic and serious disease more frequently than other serotypes. The occurrence of the four OIs in enteropathogenic E. coli O55:H7 strains is consistent with their vertical inheritance by VTEC O157:H7/NM from this clonally related ancestor.
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