ArticleJournal of clinical microbiology2005
In vitro susceptibilities of clinical isolates of Candida species, Cryptococcus neoformans, and Aspergillus species to itraconazole: global survey of 9,359 isolates tested by clinical and laboratory standards institute broth microdilution methods.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Tinea capitis among schoolchildren in Ethiopia: A systematic review and meta analysis.PloS one · 2023Pooled it
- Trial
- Bixin fromACS omega · 2025Article
- An update on the global treatment of invasive fungal infections.Future microbiology · 2023Review
- Article
- Candida glabrata-Induced Refractory Infectious Arthritis: A Case Report and Literature Review.Mycopathologia · 2019Review
- Isolated Cutaneous Granuloma Caused by Candida glabrata: A Rare Case Report and Literature Review.Mycopathologia · 2018Review
- An Assessment of In Vitro Antifungal Activities of Efinaconazole and Itraconazole against Common Non-Dermatophyte Fungi Causing Onychomycosis.Journal of fungi (Basel, Switzerland) · 2017Article
- Triazole Resistance inChinese medical journal · 2017Article
- Epidemiology and resistance features of Acinetobacter baumannii isolates from the ward environment and patients in the burn ICU of a Chinese hospital.Journal of microbiology (Seoul, Korea) · 2016Article
- Comparative functional properties of engineered cationic antimicrobial peptides consisting exclusively of tryptophan and either lysine or arginine.Journal of medical microbiology · 2016Article
- In vitro studies of the activity of dithiocarbamate organoruthenium complexes against clinically relevant fungal pathogens.Molecules (Basel, Switzerland) · 2014Article
- Antifolates inhibit Cryptococcus biofilms and enhance susceptibility of planktonic cells to amphotericin B.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2013Article
- Identification of novel genes conferring altered azole susceptibility in Aspergillus fumigatus.FEMS microbiology letters · 2012Article
- Wild-type MIC distributions and epidemiological cutoff values for amphotericin B, flucytosine, and itraconazole and Candida spp. as determined by CLSI broth microdilution.Journal of clinical microbiology · 2012Article
- Resistance of Asian Cryptococcus neoformans serotype A is confined to few microsatellite genotypes.PloS one · 2012Article
- Canadian clinical practice guidelines for invasive candidiasis in adults.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2010Article
- Epidemiology and antifungal susceptibility of bloodstream Candida isolates in Quebec: Report on 453 cases between 2003 and 2005.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2008Article
- Single-dose pharmacokinetics of intravenous itraconazole and hydroxypropyl-beta-cyclodextrin in infants, children, and adolescents.Antimicrobial agents and chemotherapy · 2007Article
- Human beta-defensins kill Candida albicans in an energy-dependent and salt-sensitive manner without causing membrane disruption.Antimicrobial agents and chemotherapy · 2007Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The in vitro activity of itraconazole was determined against 7,299 isolates of Candida spp., 1,615 isolates of Cryptococcus neoformans, and 445 isolates of Aspergillus spp. obtained from over 200 medical centers worldwide. Itraconazole was active against all Candida spp. (96% of MICs were < or =1 microg/ml) with the exception of C. glabrata (77% of MICs were < or =1 microg/ml). Itraconazole inhibited 94% of C. krusei and 84% of other fluconazole-resistant Candida species, exclusive of C. glabrata, at a MIC of < or =1 microg/ml. Itraconazole was not active against fluconazole-resistant isolates of C. glabrata. Only modest activity was seen against C. neoformans (80% of MICs were < or =1 microg/ml); however, itraconazole showed excellent activity against Aspergillus spp. (94% of MICs were < or =1 microg/ml). These results provide an update on the antifungal activity of itraconazole against major opportunistic fungal pathogens. In light of the new intravenous formulation of itraconazole these data suggest that this agent remains a viable systemically active antifungal agent.
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