ArticleJournal of clinical microbiology2005
Diagnosis of cat scratch disease with detection of Bartonella henselae by PCR: a study of patients with lymph node enlargement.
Article in Journal of clinical microbiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 134 citations in OpenAlex.
- Uncovering the truth about cat-scratch disease.Open veterinary journal · 2025Review
- Cat-scratch disease mimicking soft tissue sarcoma in a pediatric patient.Radiology case reports · 2025Article
- Clinical and epidemiological characteristics of cat scratch disease in children from southwestern China: a retrospective analysis of mNGS-confirmed cases.Frontiers in public health · 2025Article
- Queuosine salvage inMicrobiology (Reading, England) · 2024Article
- Cat scratch disease unveils hidden breast carcinoma: A diagnostic twist.Radiology case reports · 2024Article
- Unmasking Bartonella henselae infection in the shadows of long COVID thanks to clinical metagenomics.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Queuosine Salvage inbioRxiv : the preprint server for biology · 2024Article
- Article
- Cerebral venous sinus thrombosis and skull base osteomyelitis as manifestations of cat-scratch disease in a pediatric patient: A case report and literature review.Clinical case reports · 2023Article
- Article
- Limitations of Serological Diagnosis of Typical Cat Scratch Disease and Recommendations for the Diagnostic Procedure.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2023Review
- Haemophagocytic lymphohistiocytosis associated with bartonella peliosis hepatis following kidney transplantation in a patient with HIV.The Lancet. Infectious diseases · 2022Review
- Molecular Diagnosis of Cat Scratch Disease: a 25-Year Retrospective Comparative Analysis of Various Clinical Specimens and Different PCR Assays.Microbiology spectrum · 2022Article
- Article
- Diagnosis and interpretation of testing for cat scratch disease.Proceedings (Baylor University. Medical Center) · 2022Article
- Two-year history of lymphadenopathy and fever caused by Bartonella henselae in a child.Revista do Instituto de Medicina Tropical de Sao Paulo · 2022Article
- Isolated hepatosplenic abscess from cat scratch disease in a patient with HIV.Proceedings (Baylor University. Medical Center) · 2021Article
- Bartonellosis in transplant recipients: A retrospective single center experience.World journal of transplantation · 2021Article
- Article
- Costal osteomyelitis due toJournal of bone and joint infection · 2021Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cat scratch disease (CSD) is mostly due to Bartonella henselae after inoculation of the organism through a skin injury. Since the causative bacteria cannot be easily cultured from human lymph node samples, the diagnosis usually relies on epidemiological, clinical, histological, and serological criteria (classical criteria). A study was performed to determine the diagnostic value of PCR analysis for the detection of B. henselae for the diagnosis of CSD and its place in the diagnostic strategy alongside the classical criteria. Over a 7-year period, lymph node biopsy specimens or cytopunctures from 70 patients were systematically tested by PCR for the presence of B. henselae DNA (htrA gene) in the Bacteriology Laboratory of the Hôpitaux Universitaires de Strasbourg. Serological testing by an immunofluorescence assay for B. henselae antibodies was also performed for each patient, and clinical, epidemiological, and histological data were collected. The patients were then divided into two groups according to the number of positive diagnostic criteria for CSD: 29 patients with definite CSD (two or more classical criteria) and 15 patients with possible CSD (less than two classical criteria). The remaining 26 patients for whom another diagnosis was retained were used as a control group. Among all criteria, PCR analysis had the best specificity (100%). The PCR assay for B. henselae was positive for 22 (76%; 95% confidence interval [CI95], 56.5 to 89.7%) of the 29 definite CSD patients and 3 (20%; CI95, 4.3 to 48.1%) of the 15 possible CSD patients. We then studied combinations of diagnostic criteria, including B. henselae PCR analysis. The best diagnostic performance was observed if at least two criteria were present among serologic, epidemiologic, histological, and molecular criteria.
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