ArticleBlood2005
Heterogeneity of engrafted bone-lining cells after systemic and local transplantation.
Article in Blood, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Functionally Distinctive Ptch Receptors Establish Multimodal Hedgehog Signaling in the Tooth Epithelial Stem Cell Niche.Stem cells (Dayton, Ohio) · 2019Article
- Continuing Challenges in Advancing Preclinical Science in Skeletal Cell-Based Therapies and Tissue Regeneration.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Mechanical signals promote osteogenic fate through a primary cilia-mediated mechanism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2016Article
- Intrauterine Bone Marrow Transplantation in Osteogenesis Imperfecta Mice Yields Donor Osteoclasts and Osteomacs but Not Osteoblasts.Stem cell reports · 2015Article
- Intra-Bone Marrow Transplantation of Endosteal Bone Marrow Cells Facilitates Allogeneic Hematopoietic and Stromal Cells Engraftment Dependent on Early Expression of CXCL-12.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Mesenchymal stem cell expression of stromal cell-derived factor-1β augments bone formation in a model of local regenerative therapy.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2015Article
- Total body irradiation is permissive for mesenchymal stem cell-mediated new bone formation following local transplantation.Tissue engineering. Part A · 2014Article
- A Site-Specific Integrated Col2.3GFP Reporter Identifies Osteoblasts Within Mineralized Tissue Formed In Vivo by Human Embryonic Stem Cells.Stem cells translational medicine · 2014Article
- Local transplantation is an effective method for cell delivery in the osteogenesis imperfecta murine model.International orthopaedics · 2014Article
- Modulation of Host Osseointegration during Bone Regeneration by Controlling Exogenous Stem Cells Differentiation Using a Material Approach.Biomaterials science · 2014Article
- The effect of fresh bone marrow cells on reconstruction of mouse calvarial defect combined with calvarial osteoprogenitor cells and collagen-apatite scaffold.Journal of tissue engineering and regenerative medicine · 2013Article
- Fabrication and characterization of biomimetic collagen-apatite scaffolds with tunable structures for bone tissue engineering.Acta biomaterialia · 2013Article
- A soluble granulocyte colony stimulating factor decoy receptor as a novel tool to increase hematopoietic cell homing and reconstitution in mice.Stem cells and development · 2013Article
- Osteocyte RANKL: new insights into the control of bone remodeling.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2012Review
- Hematopoietic bone marrow cells participate in endothelial, but not epithelial or mesenchymal cell renewal in adult rats.Journal of cellular and molecular medicine · 2011Article
- Osteopoietic engraftment after bone marrow transplantation: effect of inbred strain of mice.Experimental hematology · 2010Article
- Article
- Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow.The Journal of experimental medicine · 2009Article
- Article
- Bone mass and microarchitecture of irradiated and bone marrow-transplanted mice: influences of the donor strain.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The outcome of various osteoprogenitor-cell transplantation protocols was assessed using Col1a1-GFP reporter transgenic mice. The model requires the recipient mice to undergo lethal total body irradiation (TBI) followed by rescue with whole bone marrow. When the mice are rescued with total bone marrow from a Col1a1-GFP transgenic mouse, green fluorescence protein (GFP)-positive donor cells can be observed on most endosteal and trabecular bone surfaces. Although the cells express an osteoblast-restricted GFP, they fail to progress to osteocytes, do not form a mineralized matrix, and do not generate bone nodules in vitro. However when calvarial progenitor cells derived from the same transgenic mice are injected into the bone marrow space, osteogenesis by the donor cells is observed. Using different GFP colors that distinguish the donor and recipient osteoblasts, commingling of the 2 cells types is observed along the mineralizing osteoblast surface as well as within the osteocyte population of the endosteal bone. Despite the ability of the injected progenitor cells to produce bone within the injected bone, they lack the ability to form mineralized bone nodules when explanted to primary osteoblast culture. These reagents and imaging protocols will be useful in evaluating other cells having a better progenitor potential than calvarial-derived stromal cells.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.