Trial reportBMJ (Clinical research ed.)2005
Effect of multivitamin and multimineral supplements on morbidity from infections in older people (MAVIS trial): pragmatic, randomised, double blind, placebo controlled trial.
Trial report in BMJ (Clinical research ed.), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 27 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combined Vitamins and Minerals Decrease Incidence of Upper Respiratory Tract Infections in Older Persons
Effects of a Dietary Supplement on the Incidence of Acute Respiratory Infections in Susceptible Adults
Who cites it
27 citing papers in PubMed, 6 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Pooled it
- Pooled it
- Pooled it
- Antioxidant supplements for prevention of mortality in healthy participants and patients with various diseases.The Cochrane database of systematic reviews · 2012Pooled it
- Vitamin E and all-cause mortality: a meta-analysis.Current aging science · 2011Pooled it
- Measuring health-related quality of life in drug clinical trials: is it given due importance?Pharmacy world & science : PWS · 2008Pooled it
- Trial
- Trial
- Effect of antioxidants and B-group vitamins on risk of infections in patients with type 2 diabetes mellitus.Nutrients · 2013Trial
- Effect of a nutrition supplement and physical activity program on pneumonia and walking capacity in Chilean older people: a factorial cluster randomized trial.PLoS medicine · 2011Trial
- Multivitamin supplementation improves nutritional status and bone quality in aged care residents.European journal of clinical nutrition · 2009Trial
- Effect of multivitamin and multimineral supplementation on cognitive function in men and women aged 65 years and over: a randomised controlled trial.Nutrition journal · 2007Trial
- The effect of consuming multivitamin/mineral supplements on elderly quality of life: Based on randomized control trial.Journal of education and health promotion · 2021Article
- Multivitamins for acute respiratory tract infections: a rapid review.Advances in integrative medicine · 2020Article
- Perspective: Randomized Controlled Trials Are Not a Panacea for Diet-Related Research.Advances in nutrition (Bethesda, Md.) · 2016Article
- Economic analysis of nutrition interventions for chronic disease prevention: methods, research, and policy.Nutrition reviews · 2011Article
- Zinc lozenges may shorten the duration of colds: a systematic review.The open respiratory medicine journal · 2011Article
- Reexamination of a meta-analysis of the effect of antioxidant supplementation on mortality and health in randomized trials.Nutrients · 2010Article
- Factors influencing the participation of older people in clinical trials - data analysis from the MAVIS trial.The journal of nutrition, health & aging · 2010Article
- Medical care for the final years of life: "When you're 83, it's not going to be 20 years".JAMA · 2009Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine whether supplementation with multivitamins and multiminerals influences self reported days of infection, use of health services, and quality of life in people aged 65 or over.
designRandomised, placebo controlled trial, with blinding of participants, outcome assessors, and investigators.
settingCommunities associated with six general practices in Grampian, Scotland.
participants910 men and women aged 65 or over who did not take vitamins or minerals.
interventionsDaily multivitamin and multimineral supplementation or placebo for one year.
main outcome measuresPrimary outcomes were contacts with primary care for infections, self reported days of infection, and quality of life. Secondary outcomes included antibiotic prescriptions, hospital admissions, adverse events, and compliance.
resultsSupplementation did not significantly affect contacts with primary care and days of infection per person (incidence rate ratio 0.96, 95% confidence interval 0.78 to 1.19 and 1.07, 0.90 to 1.27). Quality of life was not affected by supplementation. No statistically significant findings were found for secondary outcomes or subgroups.
conclusionRoutine multivitamin and multimineral supplementation of older people living at home does not affect self reported infection related morbidity.
trial registrationISRCTN: 66376460.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.