ReviewJournal of molecular evolution1992
Revisiting junk DNA.
Review in Journal of molecular evolution, 1992. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Comparative Repeatomics Uncovers Genome Diversification in Gasteropelecidae Fishes.International journal of molecular sciences · 2026Article
- Non-Coding RNAs in Diagnostic Pathology of High-Grade Central Osteosarcoma.Diagnostics (Basel, Switzerland) · 2025Review
- From chemical metabolism to life: the origin of the genetic coding process.Beilstein journal of organic chemistry · 2017Review
- Dispensability of mammalian DNA.Genome research · 2008Article
- "Word" preference in the genomic text and genome evolution: different modes of n-tuplet usage in coding and noncoding sequences.Journal of molecular evolution · 2005Article
- Autosomal location of a new subtype of 1.688 satellite DNA of Drosophila melanogaster.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1996Article
- The role of constrained self-organization in genome structural evolution.Acta biotheoretica · 1996Review
- Tracking heterochromatin.Chromosoma · 1995Article
- Reverse transcriptase: mediator of genomic plasticity.Virus genes · 1995Review
- Evolution of regulatory genes and patterns: relationships to evolutionary rates and to metabolic functions.Journal of molecular evolution · 1993Article
- Code domains in tandem repetitive DNA sequence structures.Chromosoma · 1992Review
- Evolutionary consequences of nonrandom damage and repair of chromatin domains.Journal of molecular evolution · 1992Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The distribution of functions within genomes of higher organisms relative to processes that lead to the spread of mutations in populations is examined in its general outlines. A number of points are enumerated that collectively put in question the concept of junk DNA: the plausible compatibility of DNA function with rapid substitution rates; the likelihood of superimposed functions along much of eukaryotic DNA; the potential for a merely conditional functionality in sequence repeats; the apparent adoption of macromolecular waste as a strategy for maintaining a function without selective grooming of individual sequence repeats that carry out the function; the likely requirement that any DNA sequence must be "polite" vis-'a-vis (compatible with) functional sequences in its genomic environment; the existence in germ-cell lineages of selective constraints that are not apparent in populations of individuals; and the fact that DNA techtonics - the appearance and disappearance of genomic DNA - are not incompatible with function. It is pointed out that the inverse correlation between functional constraints and rates of substitution cannot be claimed to be pillar of the neutral theory, because it is also predicted from a selectionist viewpoint. The dispensability of functional structures is brought into relation with the concept of reproductive sufficiency the survivability of genotypes in the absence of fitter alleles.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.