ArticleAmerican journal of human genetics2005
Genetic evidence for a distinct subtype of schizophrenia characterized by pervasive cognitive deficit.
Article in American journal of human genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A Systematic Review of Studies Reporting Data-Driven Cognitive Subtypes across the Psychosis Spectrum.Neuropsychology review · 2020Pooled it
- Neurological soft signs in schizophrenia: a meta-analysis.Schizophrenia bulletin · 2010Pooled it
- Associations Between Klotho Levels,Schizophrenia bulletin open · 2025Article
- Pathways from developmental vulnerabilities in early childhood to schizotypy in middle childhood.The British journal of clinical psychology · 2023Article
- Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders.Science advances · 2022Article
- Relationship between Dynamic Blood-Oxygen-Level-Dependent Activity and Functional Network Connectivity: Characterization of Schizophrenia Subgroups.Brain connectivity · 2021Article
- Independent vector analysis for common subspace analysis: Application to multi-subject fMRI data yields meaningful subgroups of schizophrenia.NeuroImage · 2020Article
- Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype.Molecular psychiatry · 2020Article
- Transdiagnostic neurocognitive subgroups and functional course in young people with emerging mental disorders: a cohort study.BJPsych open · 2020Article
- Polygenic Risk Scores for Subtyping of Schizophrenia.Schizophrenia research and treatment · 2020Article
- The dialectic of quantity and quality in psychopathology.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2018Article
- Assessment of Cognition and Personality as Potential Endophenotypes in the Western Australian Family Study of Schizophrenia.Schizophrenia bulletin · 2018Article
- Using human brain imaging studies as a guide toward animal models of schizophrenia.Neuroscience · 2016Review
- Variation and validation: the example of schizophrenia.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2016Article
- Hierarchical Classes Analysis (HICLAS): A novel data reduction method to examine associations between biallelic SNPs and perceptual organization phenotypes in schizophrenia.Schizophrenia research. Cognition · 2015Article
- Can genomics help usher schizophrenia into the age of RDoC and DSM-6?Schizophrenia bulletin · 2015Article
- Uncovering the hidden risk architecture of the schizophrenias: confirmation in three independent genome-wide association studies.The American journal of psychiatry · 2015Article
- Multivariate neuroanatomical classification of cognitive subtypes in schizophrenia: a support vector machine learning approach.NeuroImage. Clinical · 2014Article
- Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia.Molecular psychiatry · 2013Article
- Patterns of deficits in brain function in bipolar disorder and schizophrenia: a cluster analytic study.Psychiatry research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel phenotyping strategy in schizophrenia, targeting different neurocognitive domains, neurobehavioral features, and selected personality traits, has allowed us to identify a homogeneous familial subtype of the disease, characterized by pervasive neurocognitive deficit. Our genome scan data indicate that this subtype, which accounts for up to 50% of our sample, has a distinct genetic basis and explains linkage to chromosome 6p24 reported previously. If representative of other populations, the ratio of schizophrenia subtypes observed in our families could have a profound impact on sample heterogeneity and on the power of genetic studies to detect linkage and association. Our proposed abbreviated battery of tests should facilitate phenotype characterization for future genetic analyses and allow a focus on a crisply defined schizophrenia subtype, thus promoting a more informed search for susceptibility genes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.