ArticlePediatric nephrology (Berlin, Germany)2005
Proinflammatory cytokines and procalcitonin in children with acute pyelonephritis.
Article in Pediatric nephrology (Berlin, Germany), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 5 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 5 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- The value of procalcitonin and urinary NGAL in the prediction of acute pyelonephritis and kidney scarring in pediatric patients with a history of febrile urinary tract infection: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2026Pooled it
- The diagnostic accuracy of MMP-7 for the diagnosis for biliary atresia- a systematic review and meta-analysis.BMC pediatrics · 2025Pooled it
- Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children.The Cochrane database of systematic reviews · 2020Pooled it
- Diagnostic value of serum procalcitonin for acute pyelonephritis in infants and children with urinary tract infections: an updated meta-analysis.World journal of urology · 2016Pooled it
- Procalcitonin, C-reactive protein, and erythrocyte sedimentation rate for the diagnosis of acute pyelonephritis in children.The Cochrane database of systematic reviews · 2015Pooled it
- Urinary Tract Infections Detection with Molecular Biomarkers.Biomolecules · 2024Review
- Application of metagenomic next-generation sequencing in the diagnosis of urinary tract infection in patients undergoing cutaneous ureterostomy.Frontiers in cellular and infection microbiology · 2023Article
- Systemic T Cell Subsets and Cytokines in Patients With Homozygous Sickle Cell Disease and Asymptomatic Urinary Tract Infections in Togo.Ochsner journal · 2021Article
- Serum Interleukin-6 and Interleukin-8 are Sensitive Markers for Early Detection of Pyelonephritis and Its Prevention to Progression to Chronic Kidney Disease.International journal of preventive medicine · 2021Article
- Serum and Urine Interleukin-6 and Interleukin-8 Levels Do Not Differentiate Acute Pyelonephritis from Lower Urinary Tract Infections in Children.Journal of inflammation research · 2020Article
- Association of mRNA Levels of IL6, MMP-8, GSS in Saliva and Pyelonephritis in Children.Molecules (Basel, Switzerland) · 2019Article
- A Porcine Model for Urinary Tract Infection.Frontiers in microbiology · 2019Article
- Fully electronic urine dipstick probe for combinatorial detection of inflammatory biomarkers.Future science OA · 2018Article
- D-dimer as a marker of acute pyelonephritis in infants younger than 24 months with urinary tract infection.Pediatric nephrology (Berlin, Germany) · 2018Article
- Vitamin D deficiency is associated with urinary tract infection in children.Archives of medical science : AMS · 2018Article
- Serum cytokine profile in pediatric Sweet's syndrome: a case report.Journal of medical case reports · 2017Article
- Immunity to uropathogens: the emerging roles of inflammasomes.Nature reviews. Urology · 2017Review
- Dysbiosis of the Urinary Microbiota Associated With Urine Levels of Proinflammatory Chemokine Interleukin-8 in Female Type 2 Diabetic Patients.Frontiers in immunology · 2017Article
- Urine interleukin-6, interleukin-8 and transforming growth factor β1 in infants with urinary tract infection and asymptomatic bacteriuria.Central-European journal of immunology · 2016Article
- Is the mean platelet volume a predictive marker for the diagnosis of acute pyelonephritis in children?Clinical and experimental nephrology · 2015Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This prospective study, performed in 76 children with a urinary tract infection (UTI), evaluates the diagnostic value of procalcitonin (PCT) and proinflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) in children with acute pyelonephritis documented by dimercaptosuccinic acid scintigraphy (DMSA). Renal parenchymal involvement was assessed by (99m )Tc-DMSA scintigraphy within 7 days of admission. The diagnosis of acute pyelonephritis was confirmed only in patients with reversible lesions on scintigraphy. According to DMSA scan results, patients were divided into two groups, lower UTI or acute pyelonephritis. In acute pyelonephritis, serum PCT level was found to be significantly higher than it is in the lower UTI (p <0.001). Also, significantly higher serum proinflammatory cytokines (IL-1beta, IL-6 and TNF-alpha) levels were detected in those with acute pyelonephritis than those with lower UTI (p <0.001). We conclude that both serum PCT and proinflammatory cytokine levels may be used as accurate markers for diagnosis of acute pyelonephritis.
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