ArticleNature2005
Transcription of mammalian messenger RNAs by a nuclear RNA polymerase of mitochondrial origin.
Article in Nature, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- SUCLG1 restricts POLRMT succinylation to enhance mitochondrial biogenesis and leukemia progression.The EMBO journal · 2024Article
- Zooming in: PAGE-Northern Blot Helps to Analyze Anti-Sense Transcripts Originating from Human rIGS under Transcriptional Stress.Non-coding RNA · 2021Article
- POLRMT mutations impair mitochondrial transcription causing neurological disease.Nature communications · 2021Article
- Pathogenetic Role and Clinical Implications of Regulatory RNAs in Biliary Tract Cancer.Cancers · 2020Review
- Mitonuclear Interactions in the Maintenance of Mitochondrial Integrity.Life (Basel, Switzerland) · 2020Review
- Long Non-Coding RNAs in Biliary Tract Cancer-An Up-to-Date Review.Journal of clinical medicine · 2020Review
- Targeting mitochondrial RNA polymerase in acute myeloid leukemia.Oncotarget · 2015Article
- Yeast Mitochondrial Transcription Factor Mtf1 Determines the Precision of Promoter-Directed Initiation of RNA Polymerase Rpo41.PloS one · 2015Article
- POLRMT does not transcribe nuclear genes.Nature · 2014Article
- Yeast mitochondrial RNAP conformational changes are regulated by interactions with the mitochondrial transcription factor.Nucleic acids research · 2014Article
- Mito-nuclear co-evolution: the positive and negative sides of functional ancient mutations.Frontiers in genetics · 2014Review
- Article
- Mitochondrial RNA polymerase is an essential enzyme in erythrocytic stages of Plasmodium falciparum.Molecular and biochemical parasitology · 2012Article
- Transcription factor zinc finger and BTB domain 1 is essential for lymphocyte development.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Novel classes of non-coding RNAs and cancer.Journal of translational medicine · 2012Review
- ZBTB1 is a determinant of lymphoid development.The Journal of experimental medicine · 2012Article
- The N-terminal domain of the yeast mitochondrial RNA polymerase regulates multiple steps of transcription.The Journal of biological chemistry · 2011Article
- Article
- Transcription of muscle actin genes by a nuclear form of mitochondrial RNA polymerase.PloS one · 2011Article
- Atypical transcription of microRNA gene fragments.Nucleic acids research · 2010Article
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
Transcription of eukaryotic genes is performed by three nuclear RNA polymerases, of which RNA polymerase II is thought to be solely responsible for the synthesis of messenger RNAs. Here we show that transcription of some mRNAs in humans and rodents is mediated by a previously unknown single-polypeptide nuclear RNA polymerase (spRNAP-IV). spRNAP-IV is expressed from an alternative transcript of the mitochondrial RNA polymerase gene (POLRMT). The spRNAP-IV lacks 262 amino-terminal amino acids of mitochondrial RNA polymerase, including the mitochondrial-targeting signal, and localizes to the nucleus. Transcription by spRNAP-IV is resistant to the RNA polymease II inhibitor alpha-amanitin but is sensitive to short interfering RNA specific for the POLRMT gene. The promoters for spRNAP-IV differ substantially from those used by RNA polymerase II, do not respond to transcriptional enhancers and contain a common functional sequence motif.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.