ArticleMolecular biology and evolution2005
Evolutionary change of the numbers of homeobox genes in bilateral animals.
Article in Molecular biology and evolution, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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43 citing papers in PubMed, 85 citations in OpenAlex.
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- Genome-Wide DNA Methylation Analysis of SoybeanFrontiers in plant science · 2020Article
- Extensive intraspecies cryptic variation in an ancient embryonic gene regulatory network.eLife · 2019Article
- Homeobox Genes and Hepatocellular Carcinoma.Cancers · 2019Review
- Zinc Finger-Homeodomain Transcriptional Factors (ZHDs) in Upland Cotton (Frontiers in genetics · 2018Article
- Genome-wide identification and expression analyses of the homeobox transcription factor family during ovule development in seedless and seeded grapes.Scientific reports · 2017Article
- Characterization of Rice Homeobox Genes, OsHOX22 and OsHOX24, and Over-expression of OsHOX24 in Transgenic Arabidopsis Suggest Their Role in Abiotic Stress Response.Frontiers in plant science · 2016Article
- Genome-wide analysis of homeobox gene family in legumes: identification, gene duplication and expression profiling.PloS one · 2015Article
- Massive expansion of Ubiquitination-related gene families within the Chlamydiae.Molecular biology and evolution · 2014Article
- Comparative genomics provide insights into evolution of trichoderma nutrition style.Genome biology and evolution · 2014Article
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- Genome-wide identification and expression profiling of ankyrin-repeat gene family in maize.Development genes and evolution · 2013Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
It has been known that the conservation or diversity of homeobox genes is responsible for the similarity and variability of some of the morphological or physiological characters among different organisms. To gain some insights into the evolutionary pattern of homeobox genes in bilateral animals, we studied the change of the numbers of these genes during the evolution of bilateral animals. We analyzed 2,031 homeodomain sequences compiled from 11 species of bilateral animals ranging from Caenorhabditis elegans to humans. Our phylogenetic analysis using a modified reconciled-tree method suggested that there were at least about 88 homeobox genes in the common ancestor of bilateral animals. About 50-60 genes of them have left at least one descendant gene in each of the 11 species studied, suggesting that about 30-40 genes were lost in a lineage-specific manner. Although similar numbers of ancestral genes have survived in each species, vertebrate lineages gained many more genes by duplication than invertebrate lineages, resulting in more than 200 homeobox genes in vertebrates and about 100 in invertebrates. After these gene duplications, a substantial number of old duplicate genes have also been lost in each lineage. Because many old duplicate genes were lost, it is likely that lost genes had already been differentiated from other groups of genes at the time of gene loss. We conclude that both gain and loss of homeobox genes were important for the evolutionary change of phenotypic characters in bilateral animals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.