ArticleMolecular biology of the cell2005
Selective modulation of integrin-mediated cell migration by distinct ADAM family members.
Article in Molecular biology of the cell, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 93 citations in OpenAlex.
- ADAM19: biological characteristics and implications in disease pathology and clinical applications.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Expression ofInternational journal of molecular sciences · 2026Article
- Developmental dynamics of skeletal muscle can be recapitulated in vitro from pig embryonic stem cells.Stem cell reports · 2026Article
- SARS-CoV-2 mRNA vaccination-induced immunological memory in human nonlymphoid and lymphoid tissues.The Journal of clinical investigation · 2023Article
- Hypoxia-inducible factor-dependent ADAM12 expression mediates breast cancer invasion and metastasis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Integrin-α9β1 as a Novel Therapeutic Target for Refractory Diseases: Recent Progress and Insights.Frontiers in immunology · 2021Review
- Single-cell transcriptomic analysis of tissue-resident memory T cells in human lung cancer.The Journal of experimental medicine · 2019Article
- Multiple non-catalytic ADAMs are novel integrin α4 ligands.Molecular and cellular biochemistry · 2018Article
- ADAM12-L confers acquired 5-fluorouracil resistance in breast cancer cells.Scientific reports · 2017Article
- ADAM12 induction by Twist1 promotes tumor invasion and metastasis via regulation of invadopodia and focal adhesions.Journal of cell science · 2017Article
- Down regulation of ADAM33 as a Predictive Biomarker of Aggressive Breast Cancer.Scientific reports · 2017Article
- Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases.Mediators of inflammation · 2017Review
- Predominant Expression of Hybrid N-Glycans Has Distinct Cellular Roles Relative to Complex and Oligomannose N-Glycans.International journal of molecular sciences · 2016Article
- Genetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancer.BMC cancer · 2016Article
- ADAM-12 as a diagnostic marker for the proliferation, migration and invasion in patients with small cell lung cancer.PloS one · 2014Article
- Phenotypic diversity of breast cancer-related mutations in metalloproteinase-disintegrin ADAM12.PloS one · 2014Article
- Strain-induced differentiation of fetal type II epithelial cells is mediated via the integrin α6β1-ADAM17/tumor necrosis factor-α-converting enzyme (TACE) signaling pathway.The Journal of biological chemistry · 2013Article
- Identification of ILK as a new partner of the ADAM12 disintegrin and metalloprotease in cell adhesion and survival.Molecular biology of the cell · 2012Article
- Article
- ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression.Molecular cancer research : MCR · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
A disintegrin and a metalloprotease (ADAM) family members have been implicated in many biological processes. Although it is recognized that recombinant ADAM disintegrin domains can interact with integrins, little is known about ADAM-integrin interactions in cellular context. Here, we tested whether ADAMs can selectively regulate integrin-mediated cell migration. ADAMs were expressed in Chinese hamster ovary cells that express defined integrins (alpha4beta1, alpha5beta1, or both), and cell migration on full-length fibronectin or on its alpha4beta1 or alpha5beta1 binding fragments was studied. We found that ADAMs inhibit integrin-mediated cell migration in patterns dictated by the integrin binding profiles of their isolated disintegrin domains. ADAM12 inhibited cell migration mediated by the alpha4beta1 but not the alpha5beta1 integrin. ADAM17 had the reciprocal effect; it inhibited alpha5beta1- but not alpha4beta1-mediated cell migration. ADAM19 and ADAM33 inhibited migration mediated by both alpha4beta1 and alpha5beta1 integrins. A point mutation in the ADAM12 disintegrin loop partially reduced the inhibitory effect of ADAM12 on cell migration on the alpha4beta1 binding fragment of fibronectin, whereas mutations that block metalloprotease activity had no effect. Our results indicate that distinct ADAMs can modulate cell migration mediated by specific integrins in a pattern dictated, at least in part, by their disintegrin domains.
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