ArticleAnnals of the rheumatic diseases2006
Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness.
Article in Annals of the rheumatic diseases, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 95 citations in OpenAlex.
- Glucosamine therapy for treating osteoarthritis.The Cochrane database of systematic reviews · 2005Pooled it
- Trial
- Pharmacokinetic Comparison of Chitosan-Derived and Biofermentation-Derived Glucosamine in Nutritional Supplement for Bone Health.Nutrients · 2022Trial
- Comparison of glucosamine sulfate and a polyherbal supplement for the relief of osteoarthritis of the knee: a randomized controlled trial [ISRCTN25438351].BMC complementary and alternative medicine · 2007Trial
- Cartilage-adhesive/penetrating pH-responsive polyphenol-glucosamine nanoparticles alleviate osteoarthritis by matrix remodeling and immune regulation.Materials today. Bio · 2026Article
- Impact of health and lifestyle food supplements on periodontal tissues and health.Periodontology 2000 · 2022Review
- Inhibition of Distinct Proline- orBioMed research international · 2020Article
- Glucosamine and chondroitin for the treatment of osteoarthritis.World journal of orthopedics · 2017Article
- Oral Glucosamine Effect on Blood Glucose and Insulin Levels in Patients With Non-Diabetic Osteoarthritis: A Double-Blind, Placebo-Controlled Clinical Trial.Archives of rheumatology · 2016Article
- Glucosamine sulfate suppresses the expression of matrix metalloproteinase-3 in osteosarcoma cells in vitro.BMC complementary and alternative medicine · 2016Article
- Glucosamine exposure reduces proteoglycan synthesis in primary human endothelial cells in vitro.Food & nutrition research · 2016Article
- The effects of glucosamine sulfate on intervertebral disc annulus fibrosus cells in vitro.The spine journal : official journal of the North American Spine Society · 2015Article
- Glucosamine for osteoarthritis: biological effects, clinical efficacy, and safety on glucose metabolism.Arthritis · 2014Review
- Chondroitin and glucosamine in the management of osteoarthritis: an update.Current rheumatology reports · 2013Review
- O-GlcNAc cycling: a link between metabolism and chronic disease.Annual review of nutrition · 2013Review
- Crystalline glucosamine sulfate in the management of knee osteoarthritis: efficacy, safety, and pharmacokinetic properties.Therapeutic advances in musculoskeletal disease · 2012Article
- Is there any scientific evidence for the use of glucosamine in the management of human osteoarthritis?Arthritis research & therapy · 2012Review
- Non-surgical treatment of osteoarthritis-related pain in the elderly.Current reviews in musculoskeletal medicine · 2011Article
- A comprehensive review of oral glucosamine use and effects on glucose metabolism in normal and diabetic individuals.Diabetes/metabolism research and reviews · 2011Review
- Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes.Osteoarthritis and cartilage · 2009Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundOral glucosamine preparations are widely used as a treatment for osteoarthritis, purportedly functioning by a variety of mechanisms suggested by results of in vitro experiments, and generally using glucosamine concentrations well in excess of 100 micromol/l.
objectiveTo use high performance liquid chromatography with a high sensitivity Metrohm-Peak instrument for pulsed amperometric measurement of human serum glucosamine; a detection limit of 0.5 micromol/l at 1:10 serum dilution allowed measurement of low levels of glucosamine in human serum, which previously has not been possible.
methodsEighteen subjects with osteoarthritis were given 1,500 mg of commercial glucosamine sulphate after an overnight fast, and serum was then obtained at baseline and every 15-30 minutes over 3 hours, and additionally, from two subjects at 5 and 8 hours. Urine samples were collected at baseline and 3 hours after ingestion from three subjects.
resultsBaseline glucosamine was below the detection limit of 0.5 mumol/l for all subjects, but after ingestion, glucosamine was detected in 17/18 subjects, beginning to rise at 30-45 minutes to a maximum at 90-180 minutes, with a range of 1.9-11.5 micromol/l (0.34-2 microg/ml).
conclusionThis maximum concentration of 11.5 micromol/l has previously been shown to contribute less than 2% of the galactosamine incorporated into chondroitin sulphate in incubations of glucosamine with cultured human chondrocytes, and is a much lower concentration than the glucosamine concentrations claimed by other investigators to have various significant in vitro effects. This raises questions about current biological rationales for glucosamine use that were based on in vitro effects of glucosamine at much higher concentrations.
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Registered trials
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