ArticleDevelopment (Cambridge, England)2005
Genomic characterisation of a Fgf-regulated gradient-based neocortical protomap.
Article in Development (Cambridge, England), 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 76 citations in OpenAlex.
- Article
- Review
- Structural and Functional Aspects of the Neurodevelopmental GeneFrontiers in molecular neuroscience · 2021Review
- The Dynamic Proteome of Oligodendrocyte Lineage Differentiation Features Planar Cell Polarity and Macroautophagy Pathways.GigaScience · 2020Article
- The microRNA miR-21 Is a Mediator of FGF8 Action on Cortical COUP-TFI Translation.Stem cell reports · 2018Article
- Sp8 and COUP-TF1 reciprocally regulate patterning and Fgf signaling in cortical progenitors.Cerebral cortex (New York, N.Y. : 1991) · 2014Article
- Receptor tyrosine kinase (RTK) signalling in the control of neural stem and progenitor cell (NSPC) development.Molecular neurobiology · 2014Review
- Dicer is required for neural stem cell multipotency and lineage progression during cerebral cortex development.Neural development · 2013Article
- The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Tissue-specific alternative polyadenylation at the imprinted gene Mest regulates allelic usage at Copg2.Nucleic acids research · 2012Article
- Bilateral enucleation alters gene expression and intraneocortical connections in the mouse.Neural development · 2012Article
- Expression at the imprinted dlk1-gtl2 locus is regulated by proneural genes in the developing telencephalon.PloS one · 2012Article
- The developing, aging neocortex: how genetics and epigenetics influence early developmental patterning and age-related change.Frontiers in genetics · 2012Article
- MicroRNAs and Fetal Brain Development: Implications for Ethanol Teratology during the Second Trimester Period of Neurogenesis.Frontiers in genetics · 2012Article
- A lifespan analysis of intraneocortical connections and gene expression in the mouse I.Cerebral cortex (New York, N.Y. : 1991) · 2011Article
- Gene expression in the rat brain: high similarity but unique differences between frontomedial-, temporal- and occipital cortex.BMC neuroscience · 2011Article
- FGF8 acts as a classic diffusible morphogen to pattern the neocortex.Development (Cambridge, England) · 2010Article
- A novel transient glutamatergic population migrating from the pallial-subpallial boundary contributes to neocortical development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- A novel role for Dbx1-derived Cajal-Retzius cells in early regionalization of the cerebral cortical neuroepithelium.PLoS biology · 2010Article
- Tbr1 regulates regional and laminar identity of postmitotic neurons in developing neocortex.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Recent findings support a model for neocortical area formation in which neocortical progenitor cells become patterned by extracellular signals to generate a protomap of progenitor cell areas that in turn generate area-specific neurons. The protomap is thought to be underpinned by spatial differences in progenitor cell identity that are reflected at the transcriptional level. We systematically investigated the nature and composition of the protomap by genomic analyses of spatial and temporal neocortical progenitor cell gene expression. We did not find gene expression evidence for progenitor cell organisation into domains or compartments, instead finding rostrocaudal gradients of gene expression across the entire neocortex. Given the role of Fgf signalling in rostrocaudal neocortical patterning, we carried out an in vivo global analysis of cortical gene expression in Fgfr1 mutant mice, identifying consistent alterations in the expression of candidate protomap elements. One such gene, Mest, was predicted by those studies to be a direct target of Fgf8 signalling and to be involved in setting up, rather than implementing, the progenitor cell protomap. In support of this, we confirmed Mest as a direct transcriptional target of Fgf8-regulated signalling in vitro. Functional studies demonstrated that this gene has a role in establishing patterned gene expression in the developing neocortex, potentially by acting as a negative regulator of the Fgf8-controlled patterning system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.