Evidence map›Paper›PMID 16079063›Full record

ArticleEnvironmental health perspectives2005

Combustion-derived ultrafine particles transport organic toxicants to target respiratory cells.

Arthur Penn, Gleeson Murphy, Steven Barker, William Henk, Lynn Penn

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental health perspectives, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
6.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.

  1. Pooled it
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  16. Article
  17. Article
  18. Effects of fuel components and combustion particle physicochemical properties on toxicological responses of lung cells.Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering · 2018
    Article
  19. Review
  20. Neuropathological Consequences of Gestational Exposure to Concentrated Ambient Fine and Ultrafine Particles in the Mouse.Toxicological sciences : an official journal of the Society of Toxicology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Arthur PennDepartment of Comparative Biomedical Sciences, Louisiana State University, School of Veterinary Medicine, Baton Rouge, Louisiana 70803, USA. apenn@vetmed.lsu.edu
Gleeson Murphy
Steven Barker
William Henk
Lynn Penn
Louisiana State University · USUniversity of Kentucky · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epidemiologic evidence supports associations between inhalation of fine and ultrafine ambient particulate matter [aerodynamic diameter < or = 2.5 microm (PM2.5)] and increases in cardiovascular/respiratory morbidity and mortality. Less attention has been paid to how the physical and chemical characteristics of these particles may influence their interactions with target cells. Butadiene soot (BDS), produced during combustion of the high-volume petrochemical 1,3-butadiene, is rich in polynuclear aromatic hydrocarbons (PAHs), including known carcinogens. We conducted experiments to characterize BDS with respect to particle size distribution, assembly, PAH composition, elemental content, and interaction with respiratory epithelial cells. Freshly generated, intact BDS is primarily (> 90%) PAH-rich, metals-poor (nickel, chromium, and vanadium concentrations all < 1 ppm) PM2.5, composed of uniformly sized, solid spheres (30-50 nm) in aggregated form. Cells of a human bronchial epithelial cell line (BEAS-2B) exhibit sequential fluorescent responses--a relatively rapid (approximately 30 min), bright but diffuse fluorescence followed by the slower (2-4 hr) appearance of punctate cytoplasmic fluorescence--after BDS is added to medium overlying the cells. The fluorescence is associated with PAH localization in the cells. The ultrafine BDS particles move down through the medium to the cell membrane. Fluorescent PAHs are transferred from the particle surface to the cell membrane, cross the membrane into the cytosol, and appear to accumulate in lipid vesicles. There is no evidence that BDS particles pass into the cells. The results demonstrate that uptake of airborne ultrafine particles by target cells is not necessary for transfer of toxicants from the particles to the cells.

Indexed as

AdsorptionAir PollutantsBiological TransportButadienesCell LineCytoplasmic VesiclesDustEpithelial CellsGas Chromatography-Mass SpectrometryHot TemperatureHumansLungMicroscopy, Electron, ScanningMicroscopy, Electron, TransmissionParticle SizePolycyclic Aromatic HydrocarbonsAir PollutantsButadienesDustPolycyclic Aromatic Hydrocarbons

Identifiers

PMID16079063
PMCPMC1280333
OpenAlexW2079943574

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.