Evidence map›Paper›PMID 16079061›Full record

ReviewEnvironmental health perspectives2005

Potential role of ultrafine particles in associations between airborne particle mass and cardiovascular health.

Ralph J Delfino, Constantinos Sioutas, Shaista Malik

Open access · diamondAbstract readReview
In one paragraph

Review in Environmental health perspectives, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 162 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
162citing papers in PubMed, 3 pooled it
22.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

162 citing papers in PubMed, 3 syntheses or guidelines pooled it, 944 citations in OpenAlex.

  1. Meta-Analysis of Cardiac Mortality in Three Cohorts of Carbon Black Production Workers.International journal of environmental research and public health · 2016
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Estimates of submicron particulate matter (PMThe Lancet. Planetary health · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Effects of PMToxics · 2024
    Article
  18. Investigating environmentally persistent free radicals (EPFRs) emissions of 3D printing process.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2024
    Article
  19. Review
  20. Article

102 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Ralph J DelfinoEpidemiology Division, Department of Medicine, University of California, Irvine, Irvine, California 92697-7550, USA. rdelfino@uci.edu
Constantinos Sioutas
Shaista Malik
University of California, Irvine · USUniversity of Southern California · US

Funding

Ultrafine Particulate Matter &Cardiorespiratory HealthR01ES012243 · NIEHS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DELFINO, RALPH J · 2003 to 2015
$6.0M
NIEHS NIH HHS ES-12243NIEHS NIH HHS R01 ES012243
6 · The paper itself

Abstract

Numerous epidemiologic time-series studies have shown generally consistent associations of cardiovascular hospital admissions and mortality with outdoor air pollution, particularly mass concentrations of particulate matter (PM) < or = 2.5 or < or = 10 microm in diameter (PM2.5, PM10). Panel studies with repeated measures have supported the time-series results showing associations between PM and risk of cardiac ischemia and arrhythmias, increased blood pressure, decreased heart rate variability, and increased circulating markers of inflammation and thrombosis. The causal components driving the PM associations remain to be identified. Epidemiologic data using pollutant gases and particle characteristics such as particle number concentration and elemental carbon have provided indirect evidence that products of fossil fuel combustion are important. Ultrafine particles < 0.1 microm (UFPs) dominate particle number concentrations and surface area and are therefore capable of carrying large concentrations of adsorbed or condensed toxic air pollutants. It is likely that redox-active components in UFPs from fossil fuel combustion reach cardiovascular target sites. High UFP exposures may lead to systemic inflammation through oxidative stress responses to reactive oxygen species and thereby promote the progression of atherosclerosis and precipitate acute cardiovascular responses ranging from increased blood pressure to myocardial infarction. The next steps in epidemiologic research are to identify more clearly the putative PM casual components and size fractions linked to their sources. To advance this, we discuss in a companion article (Sioutas C, Delfino RJ, Singh M. 2005. Environ Health Perspect 113:947-955) the need for and methods of UFP exposure assessment.

Indexed as

Environmental ExposureAerosolsAir PollutionCardiovascular DiseasesCohort StudiesCross-Sectional StudiesDustHumansParticle SizeVehicle EmissionsAerosolsDustVehicle Emissions

Identifiers

PMID16079061
PMCPMC1280331
OpenAlexW2141007595

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.