ArticleJournal of bacteriology2005
Helicobacter pylori flagellar hook-filament transition is controlled by a FliK functional homolog encoded by the gene HP0906.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- The impact of the flagellar protein genemSphere · 2025Article
- Genetic requirements and transcriptomics of Helicobacter pylori biofilm formation on abiotic and biotic surfaces.NPJ biofilms and microbiomes · 2020Article
- Methylomic and phenotypic analysis of the ModH5 phasevarion of Helicobacter pylori.Scientific reports · 2017Article
- Role of Flagella in the Pathogenesis of Helicobacter pylori.Current microbiology · 2017Review
- Article
- The cag-pathogenicity island encoded CncR1 sRNA oppositely modulates Helicobacter pylori motility and adhesion to host cells.Cellular and molecular life sciences : CMLS · 2016Article
- The Structure of a Type 3 Secretion System (T3SS) Ruler Protein Suggests a Molecular Mechanism for Needle Length Sensing.The Journal of biological chemistry · 2016Article
- Initial characterization of the FlgE hook high molecular weight complex of Borrelia burgdorferi.PloS one · 2014Article
- Insertion mutations in Helicobacter pylori flhA reveal strain differences in RpoN-dependent gene expression.Microbiology (Reading, England) · 2013Article
- Evolution in an oncogenic bacterial species with extreme genome plasticity: Helicobacter pylori East Asian genomes.BMC microbiology · 2011Article
- Motility and chemotaxis in Campylobacter and Helicobacter .Annual review of microbiology · 2011Review
- Article
- Morphological analysis of the sheathed flagellum of Brucella melitensis.BMC research notes · 2010Article
- In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcription.BMC microbiology · 2010Article
- The HP0256 gene product is involved in motility and cell envelope architecture of Helicobacter pylori.BMC microbiology · 2010Article
- Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen.BMC genomics · 2010Article
- Sense and sensibility: flagellum-mediated gene regulation.Trends in microbiology · 2010Review
- Synergistic effect of imp/ostA and msbA in hydrophobic drug resistance of Helicobacter pylori.BMC microbiology · 2009Article
- Effect of FliK mutation on the transcriptional activity of the {sigma}54 sigma factor RpoN in Helicobacter pylori.Microbiology (Reading, England) · 2009Article
- Posttranscriptional regulation of flagellin synthesis in Helicobacter pylori by the RpoN chaperone HP0958.Journal of bacteriology · 2008Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Helicobacter pylori is a human gastric pathogen which is dependent on motility for infection. The H. pylori genome encodes a near-complete complement of flagellar proteins compared to model enteric bacteria. One of the few flagellar genes not annotated in H. pylori is that encoding FliK, a hook length control protein whose absence leads to a polyhook phenotype in Salmonella enterica. We investigated the role of the H. pylori gene HP0906 in flagellar biogenesis because of linkage to other flagellar genes, because of its transcriptional regulation pattern, and because of the properties of an ortholog in Campylobacter jejuni (N. Kamal and C. W. Penn, unpublished data). A nonpolar mutation of HP0906 in strain CCUG 17874 was generated by insertion of a chloramphenicol resistance marker. Cells of the mutant were almost completely nonmotile but produced sheathed, undulating polyhook structures at the cell pole. Expression of HP0906 in a Salmonella fliK mutant restored motility, confirming that HP0906 is the H. pylori fliK gene. Mutation of HP0906 caused a dramatic reduction in H. pylori flagellin protein production and a significant increase in production of the hook protein FlgE. The HP0906 mutant showed increased transcription of the flgE and flaB genes relative to the wild type, down-regulation of flaA transcription, and no significant change in transcription of the flagellar intermediate class genes flgM, fliD, and flhA. We conclude that the H. pylori HP0906 gene product is the hook length control protein FliK and that its function is required for turning off the sigma(54) regulon during progression of the flagellar gene expression cascade.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.